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    unc-119 unc-119 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-119provided by FlyBase
    Official Full Name
    unc-119provided by FlyBase
    Primary source
    FLYBASE:FBgn0025549
    Locus tag
    Dmel_CG1659
    See related
    AllianceGenome:FB:FBgn0025549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey123; CG1659; dm unc-119; Dmel\CG1659; DmUNC-119; Unc-119; Unc119
    Summary
    Predicted to enable lipid binding activity. Involved in nervous system development. Predicted to be active in cilium. Is expressed in several structures, including larval central nervous system; presumptive embryonic/larval central nervous system; sensory cluster; and telson. Human ortholog(s) of this gene implicated in cone-rod dystrophy 24 and immunodeficiency 13. Orthologous to human UNC119 (unc-119 lipid binding chaperone) and UNC119B (unc-119 lipid binding chaperone B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See unc-119 in Genome Data Viewer
    Location:
    7B1-7B1; 1-20 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7288367..7291298, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7182400..7185331, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44357 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene brinker Neighboring gene Autophagy-related 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The UNC-119 family of neural proteins is functionally conserved between humans, Drosophila and C. elegans. Maduro MF, et al. J Neurogenet, 2000 Jan. PMID 10858820
    2. Evidence of gene conversion associated with a selective sweep in Drosophila melanogaster. Glinka S, et al. Mol Biol Evol, 2006 Oct. PMID 16868022
    3. Repeat length of C9orf72-associated glycine-alanine polypeptides affects their toxicity. Morón-Oset J, et al. Acta Neuropathol Commun, 2023 Aug 29. PMID 37644512, Free PMC Article
    4. Genome-wide association study of sleep in Drosophila melanogaster. Harbison ST, et al. BMC Genomics, 2013 Apr 25. PMID 23617951, Free PMC Article
    5. Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo. Markstein M, et al. Proc Natl Acad Sci U S A, 2002 Jan 22. PMID 11752406, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipoprotein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    unc-119
    Names
    CG1659-PA
    CG1659-PC
    unc-119-PA
    unc-119-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7288367..7291298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298049.1 → NP_001284978.1  unc-119, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284978.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XYQ2
      UniProtKB/TrEMBL
      Q0E5K0, Q540Y4
      Conserved Domains (1) summary
      pfam05351
      Location:88 → 259
      GMP_PDE_delta; GMP-PDE, delta subunit

    2. NM_132161.5 → NP_572389.1  unc-119, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572389.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XYQ2
      UniProtKB/TrEMBL
      Q0E5K0, Q540Y4
      Related
      FBpp0071024
      Conserved Domains (1) summary
      pfam05351
      Location:88 → 259
      GMP_PDE_delta; GMP-PDE, delta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q540Y4 Q540Y4
    Q9XYQ2.1 Q9XYQ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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