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    rpt6 proteasome regulatory subunit Rpt6 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540487, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rpt6
    Official Full Name
    proteasome regulatory subunit Rpt6
    Primary source
    PomBase:SPBC23G7.12c
    Locus tag
    SPOM_SPBC23G7.12C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    let1
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    Genomic context

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    See rpt6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (2121444..2122816, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-3-methyladenine glycosylase Mag2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene urea transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast. Gatti L, et al. BMC Genomics, 2011 Jan 19. PMID 21247416, Free PMC Article
    2. The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together. Pathare GR, et al. Proc Natl Acad Sci U S A, 2012 Jan 3. PMID 22187461, Free PMC Article
    3. Isolation and characterization of Nrf1p, a novel negative regulator of the Cdc42p GTPase in Schizosaccharomyces pombe. Murray JM, et al. Genetics, 2000 Jan. PMID 10628977, Free PMC Article
    4. Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Lasker K, et al. Proc Natl Acad Sci U S A, 2012 Jan 31. PMID 22307589, Free PMC Article
    5. Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution. Bohn S, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21098295, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that rpt6 mutants exhibiting resistance to cisplatin.
      Title: Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome-activating activity ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nucleus HDA PubMed 
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome regulatory subunit Rpt6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2121444..2122816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021776.3 → NP_595870.1  proteasome regulatory subunit Rpt6 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595870.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P41836
      Conserved Domains (3) summary
      COG1222
      Location:3 → 401
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
      pfam00004
      Location:182 → 315
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam13191
      Location:149 → 202
      AAA_16; AAA ATPase domain
    Nucleotide Protein
    Heading Accession and Version

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