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    hrs1 histidine--tRNA (His) ligase Hrs1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540472, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hrs1
    Official Full Name
    histidine--tRNA (His) ligase Hrs1
    Primary source
    PomBase:SPBC2G2.12
    Locus tag
    SPOM_SPBC2G2.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See hrs1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3457165..3458912)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein mug110 Neighboring gene N-myristoyltransferase 1 Neighboring gene deoxycytidylate deaminase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chromosomes rein back the spindle pole body during horsetail movement in fission yeast meiosis. Chikashige Y, et al. Cell Struct Funct, 2014. PMID 24954111
    2. Transient structure associated with the spindle pole body directs meiotic microtubule reorganization in S. pombe. Funaya C, et al. Curr Biol, 2012 Apr 10. PMID 22425159, Free PMC Article
    3. Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. Nie M, et al. J Biol Chem, 2012 Aug 24. PMID 22730331, Free PMC Article
    4. Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast. Larochelle M, et al. J Cell Sci, 2019 May 31. PMID 31064814
    5. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histidine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in histidyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IC
    Inferred by Curator
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histidine--tRNA (His) ligase Hrs1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3457165..3458912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022360.3 → NP_596441.2  histidine--tRNA (His) ligase Hrs1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596441.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O43011
      Conserved Domains (4) summary
      COG0124
      Location:86 → 561
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd00773
      Location:101 → 444
      HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00859
      Location:458 → 557
      HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
      pfam00458
      Location:33 → 62
      WHEP-TRS; WHEP-TRS domain
    Nucleotide Protein
    Heading Accession and Version

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