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    NSE5 Smc5-Smc6 complex subunit NSE5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854985, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NSE5
    Official Full Name
    Smc5-Smc6 complex subunit NSE5
    Primary source
    SGD:S000004485
    Locus tag
    YML023C
    See related
    AllianceGenome:SGD:S000004485; FungiDB:YML023C; VEuPathDB:YML023C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATPase inhibitor activity. Contributes to SUMO transferase activity. Involved in DNA repair. Located in nucleus. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NSE5 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (226994..228664, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL6 Neighboring gene ribosomal 40S subunit protein S17A Neighboring gene adenine phosphoribosyltransferase APT1 Neighboring gene uracil-DNA glycosylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Anaphase onset before complete DNA replication with intact checkpoint responses. Torres-Rosell J, et al. Science, 2007 Mar 9. PMID 17347440
    2. Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes. Yu Y, et al. Proc Natl Acad Sci U S A, 2022 Jun 7. PMID 35648833, Free PMC Article
    3. Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding. Taschner M, et al. EMBO J, 2021 Aug 2. PMID 34191293, Free PMC Article
    4. Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex. Hallett ST, et al. Nucleic Acids Res, 2021 May 7. PMID 33849072, Free PMC Article
    5. Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions. Li S, et al. Proc Natl Acad Sci U S A, 2023 Nov 7. PMID 37903273, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
      Title: Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding.
    2. Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
      Title: Nse5/6 is a negative regulator of the ATPase activity of the Smc5/6 complex.
    3. Smc5 and Smc6 associate with each other at their hinge regions and constitute the backbone of the complex, whereas the Nse1-6 subunits form three distinct subcomplexes/entities that interact with different regions of Smc5 and Smc6.
      Title: Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to SUMO transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Smc5-Smc6 complex subunit NSE5
    NP_013689.1
    • Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      226994..228664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182381.1 → NP_013689.1  TPA: Smc5-Smc6 complex subunit NSE5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013689.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZF1, Q03718
      UniProtKB/TrEMBL
      G2WK29, N1NX32
      Conserved Domains (1) summary
      pfam08691
      Location:1 → 517
      Nse5; DNA repair proteins Nse5 and Nse6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03718.1

    Gene LinkOut

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