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    mtr4 TRAMP complex ATP-dependent RNA helicase subunit Mtr4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541639, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mtr4
    Official Full Name
    TRAMP complex ATP-dependent RNA helicase subunit Mtr4
    Primary source
    PomBase:SPAC6F12.16c
    Locus tag
    SPOM_SPAC6F12.16C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mtr4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (1344924..1348489, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene anaphase-promoting complex TPR lobe subcomplex subunit Apc8 Neighboring gene anaphase-promoting complex TPR lobe subcomplex subunit Cut9/Apc6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cleavage and polyadenylation specificity factor complex subunit Rna14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein. Lemieux C, et al. Mol Cell, 2011 Oct 7. PMID 21981922
    2. RNAi-dependent and -independent RNA turnover mechanisms contribute to heterochromatic gene silencing. Bühler M, et al. Cell, 2007 May 18. PMID 17512405
    3. The THO complex cooperates with the nuclear RNA surveillance machinery to control small nucleolar RNA expression. Larochelle M, et al. Nucleic Acids Res, 2012 Nov 1. PMID 22965128, Free PMC Article
    4. Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex. Weick EM, et al. Cell, 2018 Jun 14. PMID 29906447, Free PMC Article
    5. Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance. Lee NN, et al. Cell, 2013 Nov 21. PMID 24210919, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA helicase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyadenylation-dependent ncRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in siRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAMP complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAMP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    TRAMP complex ATP-dependent RNA helicase subunit Mtr4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1344924..1348489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356009.2 → NP_001342839.1  TRAMP complex ATP-dependent RNA helicase subunit Mtr4 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14232, Q9USD3
      Conserved Domains (1) summary
      COG4581
      Location:52 → 1117
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version

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