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    CLB3 B-type cyclin CLB3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851400, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CLB3
    Official Full Name
    B-type cyclin CLB3
    Primary source
    SGD:S000002314
    Locus tag
    YDL155W
    See related
    AllianceGenome:SGD:S000002314; FungiDB:YDL155W; VEuPathDB:YDL155W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including G2/M transition of mitotic cell cycle; meiosis II; and regulation of cell cycle process. Located in cytoplasm; lipid droplet; and nucleus. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to human CCNB1 (cyclin B1) and CCNB2 (cyclin B2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CLB3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (176773..178056)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Dmo2p Neighboring gene Cmr1p Neighboring gene MutS family protein MSH5 Neighboring gene rRNA-processing protein SAS10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel and highly divergent Arabidopsis cyclin isolated by complementation in budding yeast. Abrahams S, et al. Biochim Biophys Acta, 2001 May 28. PMID 11389963
    2. Isolation and characterisation of a mutation in the PMR1 gene encoding a Golgi membrane ATPase, which causes hypersensitivity to over-expression of Clb3 in Saccharomyces cerevisiae. Funakoshi M, et al. Mol Gen Genet, 2000 Sep. PMID 11016830
    3. TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast. Zachariae W, et al. Mol Biol Cell, 1996 May. PMID 8744951, Free PMC Article
    4. Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis. Berchowitz LE, et al. Cell, 2015 Oct 8. PMID 26411291, Free PMC Article
    5. Identification and characterization of individual cyclin-dependent kinase complexes from Saccharomyces cerevisiae. Shellman YG, et al. Yeast, 1999 Mar 15. PMID 10206189

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulated mitotic proteolysis of Clb3 is specifically required to make passage of Start in the succeeding cell cycle.
      Title: Degradation of the Mitotic Cyclin Clb3 Is not Required for Mitotic Exit but Is Necessary for G1 Cyclin Control of the Succeeding Cell Cycle.
    2. Deletion of CLB1 or CLB3 allows cdc14-arrested cells to complete cytokinesis, but not cell separation
      Title: Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase.
    3. SIC1-0P (all nine phosphorylation sites mutated) was lethal when combined with deletion of CLB2, CLB3, or CLB5; failure of Sic1 phosphorylation and proteolysis imposes a variable cell cycle delay and extreme sensitivity to B-type cyclin dosage
      Title: Phosphorylation of the Sic1 inhibitor of B-type cyclins in Saccharomyces cerevisiae is not essential but contributes to cell cycle robustness.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiosis II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic spindle pole body separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mitotic spindle assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    B-type cyclin CLB3
    NP_010126.1
    • B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress; CLB3 has a paralog, CLB4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      176773..178056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180215.1 → NP_010126.1  TPA: B-type cyclin CLB3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010126.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRJ5, P24870
      UniProtKB/TrEMBL
      A6ZXH4, B3LH42, C8Z6E9, G2WC08, N1P7U2
      Conserved Domains (1) summary
      COG5024
      Location:4 → 421
      COG5024; Cyclin [Cell division and chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24870.3

    Gene LinkOut

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