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    myo52 myosin type V [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538846, updated on 14-Nov-2024

    Summary

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    Official Symbol
    myo52
    Official Full Name
    myosin type V
    Primary source
    PomBase:SPCC1919.10c
    Locus tag
    SPOM_SPCC1919.10C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    myo4
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    Genomic context

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    See myo52 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003421.2 (2224882..2229940, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene mitochondrial 54S ribosomal protein uL30m Neighboring gene translation initiation factor-like ribosome biogenesis protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BAR adaptor protein Mug137 Neighboring gene aminopeptidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of two type V myosins in fission yeast, one of which functions in polarized cell growth and moves rapidly in the cell. Motegi F, et al. Mol Biol Cell, 2001 May. PMID 11359928, Free PMC Article
    2. Myosin V-mediated vacuole distribution and fusion in fission yeast. Mulvihill DP, et al. Curr Biol, 2001 Jul 24. PMID 11509236
    3. Two type V myosins with non-overlapping functions in the fission yeast Schizosaccharomyces pombe: Myo52 is concerned with growth polarity and cytokinesis, Myo51 is a component of the cytokinetic actin ring. Win TZ, et al. J Cell Sci, 2001 Jan. PMID 11112691
    4. A critical role for the type V myosin, Myo52, in septum deposition and cell fission during cytokinesis in Schizosaccharomyces pombe. Mulvihill DP, et al. Cell Motil Cytoskeleton, 2006 Mar. PMID 16421926
    5. In vivo movement of the type V myosin Myo52 requires dimerisation but is independent of the neck domain. Grallert A, et al. J Cell Sci, 2007 Dec 1. PMID 18003699

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rng8 and Rng9 accumulate on the fusion focus, dependent on Myo51 and tropomyosin Cdc8. A tropomyosin mutant allele, which compromises Rng8/9 localization but not actin binding, similarly leads to multiple stable dots instead of a single focus. By contrast, myo51 deletion does not strongly affect fusion focus coalescence
      Title: A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
    2. Myo52p lacking cargo, or single molecules of wild-type Myo52p with small cargoes, can undergo processive movement along actin-Cdc8p cables in vivo.
      Title: Fission yeast tropomyosin specifies directed transport of myosin-V along actin cables.
    3. Myo52 motor activity may pull on cables to provide the tension necessary for their extension and efficient assembly, as artificially tethering actin cables to the nuclear envelope via a Myo52 motor domain
      Title: Myosin Vs organize actin cables in fission yeast.
    4. Myo52 facilitates microtubule catastrophe by enhancing Tip1 removal from the plus end of growing microtubules at the cell tips.
      Title: Myosin V spatially regulates microtubule dynamics and promotes the ubiquitin-dependent degradation of the fission yeast CLIP-170 homologue, Tip1.
    5. In vivo movement of the type V myosin Myo52 requires dimerization but is independent of the neck domain.
      Title: In vivo movement of the type V myosin Myo52 requires dimerisation but is independent of the neck domain.
    6. Form of myosin type V, transports Bgs1 to the cell equator, thus ensuring the accurate deposition of beta-1,3-glucan at the leading edge of the primary septum.
      Title: A critical role for the type V myosin, Myo52, in septum deposition and cell fission during cytokinesis in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament bundle retrograde transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formin-nucleated actin cable assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to cell cortex of cell tip IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport to mating projection actin fusion focus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle transport along actin filament IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell cortex of cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex of growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site HDA PubMed 
    is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell tip HDA PubMed 
    is_active_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cortical dynamic polarity patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lateral cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mating projection actin fusion focus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in medial cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin type V

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      2224882..2229940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023482.3 → NP_588492.1  myosin type V [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588492.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94477, P78899, Q9US73
      Conserved Domains (3) summary
      COG5022
      Location:1 → 1501
      COG5022; Myosin heavy chain [General function prediction only]
      cd15474
      Location:1105 → 1434
      Myo5p-like_CBD_fungal; cargo binding domain of fungal myosin V -like proteins
      cd01380
      Location:87 → 754
      MYSc_Myo5; class V myosin, motor domain
    Nucleotide Protein
    Heading Accession and Version

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