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    msy2 MS ion channel protein 2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541425, updated on 18-Sep-2024

    Summary

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    Official Symbol
    msy2
    Official Full Name
    MS ion channel protein 2
    Primary source
    PomBase:SPAC2C4.17c
    Locus tag
    SPOM_SPAC2C4.17C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See msy2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4288009..4291761, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene UBX domain protein Ubx2 Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS8 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanosensitive channels Msy1 and Msy2 are required for maintaining organelle integrity upon hypoosmotic shock in Schizosaccharomyces pombe. Nakayama Y, et al. FEMS Yeast Res, 2014 Sep. PMID 25041276
    2. Organellar mechanosensitive channels in fission yeast regulate the hypo-osmotic shock response. Nakayama Y, et al. Nat Commun, 2012. PMID 22910366
    3. Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast. Burr R, et al. J Biol Chem, 2017 Sep 29. PMID 28821619, Free PMC Article
    4. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article
    5. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Msy1 and Msy2 regulate intracellular Ca(2+) and cell volume for survival upon hypo-osmotic shock.
      Title: Organellar mechanosensitive channels in fission yeast regulate the hypo-osmotic shock response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mechanosensitive monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell volume homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cortical endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MS ion channel protein 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4288009..4291761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019949.3 → NP_594520.1  MS ion channel protein 2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594520.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14050
      Conserved Domains (2) summary
      COG0668
      Location:442 → 623
      MscS; Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis]
      pfam00924
      Location:445 → 644
      MS_channel; Mechanosensitive ion channel
    Nucleotide Protein
    Heading Accession and Version

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