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    ADP1 putative ATP-dependent permease ADP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850369, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ADP1
    Official Full Name
    putative ATP-dependent permease ADP1
    Primary source
    SGD:S000000604
    Locus tag
    YCR011C
    See related
    AllianceGenome:SGD:S000000604; FungiDB:YCR011C; VEuPathDB:YCR011C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Located in endoplasmic reticulum and fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ADP1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (133724..136873, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene amphiphysin-like protein RVS161 Neighboring gene Ady2p Neighboring gene phosphoglycerate kinase Neighboring gene DNA-directed DNA polymerase IV

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The product of the YCR105 gene located on the chromosome III from Saccharomyces cerevisiae presents homologies to ATP-dependent permeases. Purnelle B, et al. Yeast, 1991 Nov. PMID 1789009
    2. Extracellular glutathione fermentation using engineered Saccharomyces cerevisiae expressing a novel glutathione exporter. Kiriyama K, et al. Appl Microbiol Biotechnol, 2012 Nov. PMID 22526809
    3. Complete inventory of the yeast ABC proteins. Decottignies A, et al. Nat Genet, 1997 Feb. PMID 9020838
    4. Loss of APD1 in yeast confers hydroxyurea sensitivity suppressed by Yap1p transcription factor. Tang HM, et al. Sci Rep, 2015 Jan 20. PMID 25600293, Free PMC Article
    5. Control of Plasma Membrane Permeability by ABC Transporters. Khakhina S, et al. Eukaryot Cell, 2015 May. PMID 25724885, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adp1 was identified as a novel glutathione export ABC protein (Gxa1).
      Title: Extracellular glutathione fermentation using engineered Saccharomyces cerevisiae expressing a novel glutathione exporter.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative ATP-dependent permease ADP1
    NP_009937.2
    • Putative ATP-dependent permease of the ABC transporter family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      133724..136873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178724.1 → NP_009937.2  TPA: putative ATP-dependent permease ADP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009937.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR20, P25371
      UniProtKB/TrEMBL
      A6ZTJ2, C7GQM3, C8Z498, N1PAQ0
      Conserved Domains (2) summary
      TIGR00955
      Location:402 → 1042
      3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
      cl21504
      Location:70 → 90
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25371.2

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