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    CIN5 Cin5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854193, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CIN5
    Official Full Name
    Cin5p
    Primary source
    SGD:S000005554
    Locus tag
    YOR028C
    See related
    AllianceGenome:SGD:S000005554; FungiDB:YOR028C; VEuPathDB:YOR028C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HAL6; YAP4
    Summary
    Enables DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in hyperosmotic salinity response and response to xenobiotic stimulus. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CIN5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (383533..384420, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Bub3p Neighboring gene Hsp90 cochaperone STI1 Neighboring gene uncharacterized protein Neighboring gene Dfg16p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional response of Saccharomyces cerevisiae to the plasma membrane-perturbing compound chitosan. Zakrzewska A, et al. Eukaryot Cell, 2005 Apr. PMID 15821130, Free PMC Article
    2. Two nuclear proteins, Cin5 and Ydr259c, confer resistance to cisplatin in Saccharomyces cerevisiae. Furuchi T, et al. Mol Pharmacol, 2001 Mar. PMID 11179441
    3. Coevolution within a transcriptional network by compensatory trans and cis mutations. Kuo D, et al. Genome Res, 2010 Dec. PMID 20978140, Free PMC Article
    4. Quinone reductase acts as a redox switch of the 20S yeast proteasome. Sollner S, et al. EMBO Rep, 2009 Jan. PMID 19029946, Free PMC Article
    5. Expression of YAP4 in Saccharomyces cerevisiae under osmotic stress. Nevitt T, et al. Biochem J, 2004 Apr 15. PMID 14680476, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutant forms of Yap1 that are constitutively trapped in the nucleus are degraded in the absence of an oxidant signal
      Title: Proteolytic degradation of the Yap1 transcription factor is regulated by subcellular localization and the E3 ubiquitin ligase Not4.
    2. Yap4 activity is maintained in the absence of phosphorylation. However, this modification seems to be required for stability of the protein, as the non-phosphorylated form has a shorter half-life than the phosphorylated one.
      Title: Yap4 PKA- and GSK3-dependent phosphorylation affects its stability but not its nuclear localization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding HDA PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hyperosmotic response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cin5p
    NP_014671.1
    • Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      383533..384420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183447.1 → NP_014671.1  TPA: Cin5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014671.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W294, P40917
      UniProtKB/TrEMBL
      A6ZNN2, B3LJ82, B5VRT0, C7GLF8, G2WMQ9
      Conserved Domains (2) summary
      cd14688
      Location:240 → 291
      bZIP_YAP; coiled coil [structural motif]
      pfam00170
      Location:239 → 294
      bZIP_1; bZIP transcription factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40917.1

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