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    pub1 HECT-type ubiquitin-protein ligase E3 Pub1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541818, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pub1
    Official Full Name
    HECT-type ubiquitin-protein ligase E3 Pub1
    Primary source
    PomBase:SPAC11G7.02
    Locus tag
    SPOM_SPAC11G7.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pub1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003424.3 (3963066..3966172)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein Mtl2 Neighboring gene ncRNA Neighboring gene isocitrate dehydrogenase (NAD+) subunit 1 Idh1 Neighboring gene ubiquitin-60S ribosomal protein L40 fusion protein Neighboring gene S-malonyltransferase Mct1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3. Wang T, et al. Life Sci Alliance, 2022 May. PMID 35121625, Free PMC Article
    2. The pub1 E3 ubiquitin ligase negatively regulates leucine uptake in response to NH(4)(+) in fission yeast. Karagiannis J, et al. Curr Genet, 1999 Jul. PMID 10467003
    3. The novel HECT-type ubiquitin-protein ligase Pub2p shares partially overlapping function with Pub1p in Schizosaccharomyces pombe. Tamai KK, et al. J Cell Sci, 2002 May 1. PMID 11956316
    4. Tolerance of low pH in Schizosaccharomyces pombe requires a functioning pub1 ubiquitin ligase. Saleki R, et al. Mol Gen Genet, 1997 May 20. PMID 9197411
    5. Urea enhances cell lysis of Schizosaccharomyces pombe ura4 mutants. Nishino K, et al. Biosci Biotechnol Biochem, 2017 Jul. PMID 28345447

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3.
      Title: Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3.
    2. a novel role for Pub1 in endocytosis of Ecm33 and regulation of cell wall integrity in fission yeast [Pub1][Ecm33]
      Title: E3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast.
    3. Pub1 altered the localization of the uracil transporter Fur4 from the Golgi locus and vacuoles to the plasma membrane.
      Title: Cell Lysis in S. pombe ura4 Mutants Is Suppressed by Loss of Functional Pub1, Which Regulates the Uracil Transporter Fur4.
    4. the TSC-Rheb signaling pathway regulates the localization of amino acid transporters via Pub1 and Any1 in a Tor2-independent manner.
      Title: The fission yeast β-arrestin-like protein Any1 is involved in TSC-Rheb signaling and the regulation of amino acid transporters.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables phospholipid binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasm to vacuole targeting by the NVT pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of L-leucine import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of uracil import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus HDA PubMed 
    is_active_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HECT-type ubiquitin-protein ligase E3 Pub1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3963066..3966172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019819.3 → NP_594396.1  HECT-type ubiquitin-protein ligase E3 Pub1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594396.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14454, Q92462
      Conserved Domains (5) summary
      cd08382
      Location:9 → 131
      C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
      smart00456
      Location:346 → 378
      WW; Domain with 2 conserved Trp (W) residues
      COG5021
      Location:1 → 767
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00078
      Location:413 → 765
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:290 → 319
      WW; WW domain
    Nucleotide Protein
    Heading Accession and Version

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