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    cul4 CLRC complex subunit, cullin 4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543116, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cul4
    Official Full Name
    CLRC complex subunit, cullin 4
    Primary source
    PomBase:SPAC3A11.08
    Locus tag
    SPOM_SPAC3A11.08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    Cul-4; pcu4
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    Genomic context

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    See cul4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3452945..3455747)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene dipeptidyl peptidase Neighboring gene plasma membrane sodium ion/proton antiporter Sod22 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NADH dehydrogenase Neighboring gene ncRNA Neighboring gene sorting nexin Mvp1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RFTS domain of Raf2 is required for Cul4 interaction and heterochromatin integrity in fission yeast. White SA, et al. PLoS One, 2014. PMID 25090107, Free PMC Article
    2. Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin. Jia S, et al. Nat Cell Biol, 2005 Oct. PMID 16127433
    3. TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation. Wei Y, et al. Nat Cell Biol, 2021 Mar. PMID 33574613, Free PMC Article
    4. The Clr7 and Clr8 directionality factors and the Pcu4 cullin mediate heterochromatin formation in the fission yeast Schizosaccharomyces pombe. Thon G, et al. Genetics, 2005 Dec. PMID 16157682, Free PMC Article
    5. CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing. Kuscu C, et al. Proc Natl Acad Sci U S A, 2014 Feb 4. PMID 24449894, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of biochemical interactions demonstrates that the RFTS domain mediates an interaction between Raf2 and the CLRC component Cul4
      Title: The RFTS domain of Raf2 is required for Cul4 interaction and heterochromatin integrity in fission yeast.
    2. Components of the Clr4 histone K3-K9 methyltransferase-Rik1-Cullin4 complex act concertedly at an early step in heterochromatin formation.
      Title: A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation.
    3. Data demonstrate that Cdt2, an unstable WD40 protein, is a regulatory subunit of Pcu4-Ddb1-CSN ubiquitin ligase
      Title: Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in siRNA-mediated pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription-coupled nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CLRC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul4-RING E3 ubiquitin ligase complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in subtelomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CLRC complex subunit, cullin 4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3452945..3455747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019619.3 → NP_594195.1  CLRC complex subunit, cullin 4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594195.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14122, Q9USB6
      Conserved Domains (3) summary
      smart00182
      Location:416 → 554
      CULLIN; Cullin
      smart00884
      Location:663 → 730
      Cullin_Nedd8; Cullin protein neddylation domain
      COG5647
      Location:1 → 734
      COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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