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    rad31 SUMO activating enzyme E1-type Rad31 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543606, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rad31
    Official Full Name
    SUMO activating enzyme E1-type Rad31
    Primary source
    PomBase:SPAC4C5.04
    Locus tag
    SPOM_SPAC4C5.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    uba4
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    Genomic context

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    See rad31 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003424.3 (1198391..1199733)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Ala Neighboring gene multispanning membrane protein, CTNS/PQ domain protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance. Xhemalce B, et al. EMBO J, 2004 Oct 1. PMID 15359282, Free PMC Article
    2. SUMO modification of Rad22, the Schizosaccharomyces pombe homologue of the recombination protein Rad52. Ho JC, et al. Nucleic Acids Res, 2001 Oct 15. PMID 11600706, Free PMC Article
    3. Characterisation of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance. Shayeghi M, et al. Nucleic Acids Res, 1997 Mar 15. PMID 9092625, Free PMC Article
    4. SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage. Wei Y, et al. Mol Cell, 2017 Jun 1. PMID 28552615
    5. Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation. Xu X, et al. Proc Natl Acad Sci U S A, 2019 May 28. PMID 31072933, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IC
    Inferred by Curator
    more info
    		  
    enables SUMO activating enzyme activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables SUMO activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic chromosome condensation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein sumoylation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SUMO activating enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    SUMO activating enzyme E1-type Rad31

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1198391..1199733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018648.3 → NP_593251.1  SUMO activating enzyme E1-type Rad31 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593251.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P79064
      Conserved Domains (2) summary
      COG0476
      Location:4 → 184
      ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]
      cd01492
      Location:11 → 305
      Aos1_SUMO; Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    Nucleotide Protein
    Heading Accession and Version

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