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    YIA6 NAD+ transporter [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854811, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YIA6
    Official Full Name
    NAD+ transporter
    Primary source
    SGD:S000001268
    Locus tag
    YIL006W
    See related
    AllianceGenome:SGD:S000001268; FungiDB:YIL006W; VEuPathDB:YIL006W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NDT1
    Summary
    Enables NAD transmembrane transporter activity. Involved in NAD transmembrane transport and mitochondrial pyruvate transmembrane transport. Located in mitochondrion. Orthologous to human SLC25A32 (solute carrier family 25 member 32). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YIA6 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (344062..345183)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene ubiquitin-related modifier URM1 Neighboring gene Nas2p Neighboring gene protein disulfide isomerase EPS1 Neighboring gene Bet1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterisation of a new class of highly specific and potent inhibitors of the mitochondrial pyruvate carrier. Hildyard JC, et al. Biochim Biophys Acta, 2005 Apr-May. PMID 15863100
    2. Subcellular Distribution of NAD+ between Cytosol and Mitochondria Determines the Metabolic Profile of Human Cells. VanLinden MR, et al. J Biol Chem, 2015 Nov 13. PMID 26432643, Free PMC Article
    3. Deletion or overexpression of mitochondrial NAD+ carriers in Saccharomyces cerevisiae alters cellular NAD and ATP contents and affects mitochondrial metabolism and the rate of glycolysis. Agrimi G, et al. Appl Environ Microbiol, 2011 Apr. PMID 21335394, Free PMC Article
    4. Altered Expression of Mitochondrial NAD(+) Carriers Influences Yeast Chronological Lifespan by Modulating Cytosolic and Mitochondrial Metabolism. Orlandi I, et al. Front Genet, 2018. PMID 30619489, Free PMC Article
    5. Identification of the mitochondrial NAD+ transporter in Saccharomyces cerevisiae. Todisco S, et al. J Biol Chem, 2006 Jan 20. PMID 16291748

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NAD transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables NAD transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleotide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NAD transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in NAD transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial pyruvate transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NAD+ transporter
    NP_012260.1
    • Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; YIA6 has a paralog, YEA6, that arose from the whole genome duplication; human NAD+ transporter MCART1/SLC25A51 functionally complements the yia6 yea6 double null mutant, and yeast YIA6 reciprocally complements defects in MCART1/SLC25A51 null cells

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      344062..345183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179356.1 → NP_012260.1  TPA: NAD+ transporter [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012260.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVS4, P40556
      UniProtKB/TrEMBL
      A6ZVR2, B3LTL5, B5VKT1, C7GJH7, N1P479
      Conserved Domains (1) summary
      pfam00153
      Location:75 → 171
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40556.1

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