pab2 poly(A)-binding protein Pab2 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: pab2
Official Full Name: poly(A)-binding protein Pab2
Primary source: PomBase:SPBC16E9.12c
Locus tag: SPOM_SPBC16E9.12C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: SPBC16E6.12c
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Genomic context

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See pab2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003423.3 (1939371..1940788, complement)

Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Whereas PABPN1 strongly increases the activity of its cognate poly(A) polymerase in vitro, Pab2 was unable to stimulate Pla1 to any significant extent.
Title: The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation.
Pab2 functions with Rrp6 to negatively control Tf2 mRNA accumulation. the absence of Pab2 attenuated the derepression of Tf2 transcription and the increased frequency of Tf2 mobilization caused by the deletion of abp1.
Title: Multiple Transcriptional and Post-transcriptional Pathways Collaborate to Control Sense and Antisense RNAs of Tf2 Retroelements in Fission Yeast.
Nab2 impedes Pab2/Rrp6-mediated decay by competing with Pab2 for polyadenylated transcripts in the nucleus.
Title: Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay.
A proline-tyrosine nuclear localization signal is necessary and sufficient for nuclear import of Pab2.
Title: A proline-tyrosine nuclear localization signal (PY-NLS) is required for the nuclear import of fission yeast PAB2, but not of human PABPN1.
Pab2 and the nuclear exosome subunit, Rrp6 are the main factors involved in this polyadenylation-dependent pre-mRNA degradation pathway
Title: A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein.
a model in which Mmi1 selectively targets meiotic transcripts for degradation via Pab2 and the exosome
Title: Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast.
Pab2 promotes poly(A) tail trimming from pre-snoRNAs by recruiting the nuclear exosome.
Title: The nuclear poly(A)-binding protein interacts with the exosome to promote synthesis of noncoding small nucleolar RNAs.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables lncRNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-RNA adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA catabolic process, meiosis-specific transcripts	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Mei2 nuclear dot complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cleavage body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear exosome focus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolar peripheral inclusion body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: poly(A)-binding protein Pab2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003423.3 Reference assembly

Range

1939371..1940788 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001021695.3 → NP_595794.1 poly(A)-binding protein Pab2 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_595794.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O14327

Conserved Domains (3) summary

COG0724
Location:1 → 138

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12306
Location:56 → 128

RRM_II_PABPs; RNA recognition motif in type II polyadenylate-binding proteins

cl21462
Location:8 → 47

bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain