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    pof8 LARP7 family RNA-binding protein Pof8/Lar7 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542194, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pof8
    Official Full Name
    LARP7 family RNA-binding protein Pof8/Lar7
    Primary source
    PomBase:SPAC17G6.17
    Locus tag
    SPOM_SPAC17G6.17
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    lar7
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    Genomic context

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    See pof8 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3623723..3625371)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene TREX complex subunit, ATP-dependent RNA helicase Uap56 Neighboring gene ncRNA Neighboring gene sideroflexin Fsf1 Neighboring gene cleavage and polyadenylation specificity factor complex endoribonuclease subunit Ysh1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein Rqc1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins. Basu R, et al. RNA Biol, 2021 Aug. PMID 33131423, Free PMC Article
    2. The fission yeast methyl phosphate capping enzyme Bmc1 guides 2'-O-methylation of the U6 snRNA. Porat J, et al. Nucleic Acids Res, 2023 Sep 8. PMID 37403782, Free PMC Article
    3. Quality-Control Mechanism for Telomerase RNA Folding in the Cell. Hu X, et al. Cell Rep, 2020 Dec 29. PMID 33378677
    4. LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast. Mennie AK, et al. Nat Commun, 2018 Feb 8. PMID 29422503, Free PMC Article
    5. Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast. Páez-Moscoso DJ, et al. Nat Commun, 2018 Feb 8. PMID 29422664, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The fission yeast Lar7 has been identified as a member of the conserved LARP7 family. Lar7 has conserved RNA-recognition motifs, which bind telomerase RNA to protect it from exosomal degradation.
      Title: LARP7 family proteins have conserved function in telomerase assembly.
    2. Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins.
      Title: Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins.
    3. Quality-Control Mechanism for Telomerase RNA Folding in the Cell.
      Title: Quality-Control Mechanism for Telomerase RNA Folding in the Cell.
    4. Schizosaccharomyces pombe utilizes the p65-related protein Pof8 and its xRRM domain to promote assembly of RNA polymerase II-encoded telomerase RNA with TERT. Furthermore, Pof8 contributes to repression of the transcription of noncoding RNAs at telomeres.
      Title: LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast.
    5. The Pof8 is also a constitutive component of active telomerase in fission yeast.
      Title: Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables chromatin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables telomerase RNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nuclear RNA surveillance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomerase RNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomerase catalytic core complex assembly EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in telomerase catalytic core complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome, telomeric repeat region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    part_of sno(s)RNA-containing ribonucleoprotein complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of telomerase holoenzyme complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of telomerase holoenzyme complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LARP7 family RNA-binding protein Pof8/Lar7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3623723..3625371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019687.3 → NP_594264.1  LARP7 family RNA-binding protein Pof8/Lar7 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594264.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13795
      Conserved Domains (1) summary
      cl17169
      Location:330 → 398
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version

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