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    carbonyl reductase (NADPH-dependent) [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852154, updated on 9-Dec-2024

    Summary

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    Official Full Name
    carbonyl reductase (NADPH-dependent)
    Primary source
    SGD:S000002949
    Locus tag
    YDR541C
    See related
    AllianceGenome:SGD:S000002949; FungiDB:YDR541C; VEuPathDB:YDR541C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aldehyde dehydrogenase (NADP+) activity. Involved in response to furfural. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1519664..1520698, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative phenylacrylic acid decarboxylase FDC1 Neighboring gene Irc4p Neighboring gene seripauperin PAU10 Neighboring gene Y' element ATP-dependent helicase protein 1 copy 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel NADPH-dependent aldehyde reductase gene from Saccharomyces cerevisiae NRRL Y-12632 involved in the detoxification of aldehyde inhibitors derived from lignocellulosic biomass conversion. Liu ZL, et al. Gene, 2009 Oct 1. PMID 19577617
    2. Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp from Saccharomyces cerevisiae. Moon J, et al. Yeast, 2015 Apr. PMID 25656103
    3. Exploring redundancy in the yeast genome: an improved strategy for use of the cre-loxP system. Delneri D, et al. Gene, 2000 Jul 11. PMID 10903444
    4. A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids. Pyne ME, et al. Nat Commun, 2020 Jul 3. PMID 32620756, Free PMC Article
    5. Stereoselective, biocatalytic reductions of alpha-chloro-beta-keto esters. Kaluzna IA, et al. J Org Chem, 2005 Jan 7. PMID 15624945

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YDR541C and YGL039W encoded an aldehyde reductase.
      Title: Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp from Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to furfural IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    carbonyl reductase (NADPH-dependent)
    NP_010830.4
    • Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1519664..1520698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180849.4 → NP_010830.4  TPA: carbonyl reductase (NADPH-dependent) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010830.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTG0, Q03049
      UniProtKB/TrEMBL
      N1PAM2
      Conserved Domains (1) summary
      cd05227
      Location:4 → 320
      AR_SDR_e; aldehyde reductase, extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03049.2

    Gene LinkOut

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