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    ERI1 Eri1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856008, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERI1
    Official Full Name
    Eri1p
    Primary source
    SGD:S000028423
    Locus tag
    YPL096C-A
    See related
    AllianceGenome:SGD:S000028423; FungiDB:YPL096C-A; VEuPathDB:YPL096C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RIN1
    Summary
    Enables GTPase inhibitor activity. Involved in GPI anchor biosynthetic process and Ras protein signal transduction. Located in endoplasmic reticulum membrane. Part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERI1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (366529..366735, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mgr2p Neighboring gene tyrosine--tRNA ligase MSY1 Neighboring gene peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase Neighboring gene medium-chain fatty acid ethyl ester synthase/esterase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel Ras inhibitor, Eri1, engages yeast Ras at the endoplasmic reticulum. Sobering AK, et al. Mol Cell Biol, 2003 Jul. PMID 12832483, Free PMC Article
    2. Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER. Sobering AK, et al. Cell, 2004 May 28. PMID 15163411
    3. Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum. Kajiwara K, et al. Mol Biol Cell, 2008 May. PMID 18287539, Free PMC Article
    4. Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae. Kastenmayer JP, et al. Genome Res, 2006 Mar. PMID 16510898, Free PMC Article
    5. The initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-Y, a seventh component. Murakami Y, et al. Mol Biol Cell, 2005 Nov. PMID 16162815, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Eri1p
    NP_690846.1
    • Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic reticulum (ER); component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      366529..366735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184515.1 → NP_690846.1  TPA: Eri1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_690846.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3S0, P62651
      UniProtKB/TrEMBL
      A6ZWF4, B3LKX6, C7GJ51, C8ZIT3, G2WP84
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62651.1

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