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    IPI1 Ipi1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856485, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IPI1
    Official Full Name
    Ipi1p
    Primary source
    SGD:S000001127
    Locus tag
    YHR085W
    See related
    AllianceGenome:SGD:S000001127; FungiDB:YHR085W; VEuPathDB:YHR085W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables chromatin binding activity. Involved in pre-replicative complex assembly involved in nuclear cell cycle DNA replication; regulation of DNA-templated DNA replication initiation; and ribosomal large subunit biogenesis. Located in cytosol and nucleoplasm. Part of rixosome complex. Orthologous to human TEX10 (testis expressed 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See IPI1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (276764..277768)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene SAM complex subunit SAM35 Neighboring gene homeodomain family transcription factor STE12 Neighboring gene Nam8p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large-scale prediction of Saccharomyces cerevisiae gene function using overlapping transcriptional clusters. Wu LF, et al. Nat Genet, 2002 Jul. PMID 12089522
    2. Rea1, a dynein-related nuclear AAA-ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits. Galani K, et al. J Biol Chem, 2004 Dec 31. PMID 15528184
    3. A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits. Nissan TA, et al. Mol Cell, 2004 Jul 23. PMID 15260980
    4. Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling. Barrio-Garcia C, et al. Nat Struct Mol Biol, 2016 Jan. PMID 26619264
    5. The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis. Huo L, et al. Cell Cycle, 2012 Apr 1. PMID 22421151

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study identified the Rix1 complex members (Ipi1p-Ipi2p/Rix1-Ipi3p) as pre-replicative complex components and critical determinants of replication licensing and replication-initiation frequency
      Title: The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of rixosome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of rixosome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ipi1p
    NP_011953.1
    • Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      276764..277768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179215.1 → NP_011953.1  TPA: Ipi1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011953.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZSZ4, D3DL36, P38803
      UniProtKB/TrEMBL
      B3LSK2, B5VK17, C7GWU8, C8Z9M9, G2WFF9, N1P4K7
      Conserved Domains (1) summary
      pfam12333
      Location:125 → 216
      Ipi1_N; Rix1 complex component involved in 60S ribosome maturation
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38803.1

    Gene LinkOut

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