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    rpn12 19S proteasome regulatory subunit Rpn12 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540025, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rpn12
    Official Full Name
    19S proteasome regulatory subunit Rpn12
    Primary source
    PomBase:SPBC16G5.01
    Locus tag
    SPOM_SPBC16G5.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mts3; SPBC342.07
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    Genomic context

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    See rpn12 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (4214977..4216117)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA repair protein Neighboring gene ncRNA Neighboring gene histone lysine acetyltransferase Rtt109 Neighboring gene ncRNA Neighboring gene ribokinase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conditional lethal mutant in the fission yeast 26 S protease subunit mts3+ is defective in metaphase to anaphase transition. Gordon C, et al. J Biol Chem, 1996 Mar 8. PMID 8621436
    2. Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12. Riedinger C, et al. J Biol Chem, 2010 Oct 29. PMID 20739285, Free PMC Article
    3. The Pad1+ gene encodes a subunit of the 26 S proteasome in fission yeast. Penney M, et al. J Biol Chem, 1998 Sep 11. PMID 9727008
    4. Cdc48 is required for the stability of Cut1/separase in mitotic anaphase. Ikai N, et al. J Struct Biol, 2006 Oct. PMID 16904908
    5. SCF(Pof1)-ubiquitin and its target Zip1 transcription factor mediate cadmium response in fission yeast. Harrison C, et al. EMBO J, 2005 Feb 9. PMID 15660136, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SpRpn12 could modulate the activity of SpRpn10 as a proteasomal Ub receptor
      Title: Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    19S proteasome regulatory subunit Rpn12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4214977..4216117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023770.3 → NP_596750.2  19S proteasome regulatory subunit Rpn12 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596750.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P50524, Q9UUC3
      Conserved Domains (1) summary
      pfam10075
      Location:93 → 223
      CSN8_PSD8_EIF3K; CSN8/PSMD8/EIF3K family
    Nucleotide Protein
    Heading Accession and Version

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