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    sir2 histone deacetylase, Sirtuin family, NAD-dependent Sir2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 3361342, updated on 14-Nov-2024

    Summary

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    Official Symbol
    sir2
    Official Full Name
    histone deacetylase, Sirtuin family, NAD-dependent Sir2
    Primary source
    PomBase:SPBC16D10.07c
    Locus tag
    SPOM_SPBC16D10.07C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See sir2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003423.3 (3609217..3611686, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene plasma membrane ZIP zinc transmembrane transporter Zrt1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene heat shock protein Hsp104 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast. Shankaranarayana GD, et al. Curr Biol, 2003 Jul 15. PMID 12867036
    2. Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+. Freeman-Cook LL, et al. Genetics, 2005 Mar. PMID 15545655, Free PMC Article
    3. Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast. Alper BJ, et al. EMBO J, 2013 Aug 28. PMID 23771057, Free PMC Article
    4. Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast. Wirén M, et al. EMBO J, 2005 Aug 17. PMID 16079916, Free PMC Article
    5. Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing. Durand-Dubief M, et al. EMBO J, 2007 May 16. PMID 17446861, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly.Sir2 deacetylates H3K14 to target Clr4 to centromeres.
      Title: Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast.
    2. Sir2, together with RNAi, are sufficient to ensure heterochromatin integrity and provide evidence for sequential establishment, spreading and maintenance steps in the assembly of centromeric heterochromatin.
      Title: Distinct roles for Sir2 and RNAi in centromeric heterochromatin nucleation, spreading and maintenance.
    3. Schizosaccharomyces pombe Hst4, a homolog of histone deacetylase Sir2, participates in S-phase-specific DNA damage tolerance; it was required for the deacetylation of histone H3 core domain residue lysine 56.
      Title: Schizosaccharomyces pombe Hst4 functions in DNA damage response by regulating histone H3 K56 acetylation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K14 deacetylase activity, NAD-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K18 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 deacetylase activity, NAD-dependent EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables histone H3K4 deacetylase activity, NAD-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K56 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 deacetylase activity, NAD-dependent EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables histone H3K9 deacetylase activity, NAD-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K16 deacetylase activity, NAD-dependent EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables histone H4K16 deacetylase activity, NAD-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4K16 deacetylase activity, NAD-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to transcription corepressor activity IC
    Inferred by Curator
    more info
    		  
    Process Evidence Code Pubs
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA-independent facultative heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Set3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, subtelomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, telomeric repeat region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mating-type region heterochromatin EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in pericentric heterochromatin EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in rDNA heterochromatin EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in subtelomeric heterochromatin EXP
    Inferred from Experiment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone deacetylase, Sirtuin family, NAD-dependent Sir2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3609217..3611686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022423.3 → NP_001018840.1  histone deacetylase, Sirtuin family, NAD-dependent Sir2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_001018840.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94640, Q6H8I3
      Conserved Domains (2) summary
      cd01408
      Location:157 → 420
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
      pfam04574
      Location:70 → 162
      DUF592; Protein of unknown function (DUF592)
    Nucleotide Protein
    Heading Accession and Version

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