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    SHU1 Shu1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SHU1
    Official Full Name
    Shu1p
    Primary source
    SGD:S000000998
    Locus tag
    YHL006C
    See related
    AllianceGenome:SGD:S000000998; FungiDB:YHL006C; VEuPathDB:YHL006C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in DNA recombinase assembly and maintenance of rDNA. Located in nucleolus and site of double-strand break. Part of Shu complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SHU1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (98343..98795, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitogen-activated protein kinase kinase kinase kinase STE20 Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein MRP4 Neighboring gene sphingosine N-acyltransferase LAG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Novel, Drug Resistance-Independent, Fluorescence-Based Approach To Measure Mutation Rates in Microbial Pathogens. Shor E, et al. mBio, 2019 Feb 26. PMID 30808701, Free PMC Article
    2. Shu1 promotes homolog bias of meiotic recombination in Saccharomyces cerevisiae. Hong S, et al. Mol Cells, 2013 Nov. PMID 24213600, Free PMC Article
    3. Stalled replication forks generate a distinct mutational signature in yeast. Larsen NB, et al. Proc Natl Acad Sci U S A, 2017 Sep 5. PMID 28827358, Free PMC Article
    4. Structural and SAXS analysis of the budding yeast SHU-complex proteins. She Z, et al. FEBS Lett, 2012 Jul 30. PMID 22749910
    5. Structural analysis of Shu proteins reveals a DNA binding role essential for resisting damage. Tao Y, et al. J Biol Chem, 2012 Jun 8. PMID 22465956, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Csm2, Psy3, Shu1 and Shu2 interact with each other in sequence to form a V-shape overall structure in Shu complex.
      Title: Structural basis for the functional role of the Shu complex in homologous recombination.
    2. Result indicate that Shu1 is essential for promoting the establishment of homolog bias during meiotic homologous recombination, and the partner choice is switched by Mek1 kinase activity.
      Title: Shu1 promotes homolog bias of meiotic recombination in Saccharomyces cerevisiae.
    3. The Shu complex plays a central role in Rad52 rDNA localization as long as Rad52 can be sumoylated.
      Title: The Shu complex regulates Rad52 localization during rDNA repair.
    4. show that Shu1 regulation of Srs2 to double-strand breaks is not restricted to the ribosomal DNA, indicating a more general function for the Shu complex in the regulation of Srs2
      Title: The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase.
    5. additional mutational suppressors of toopoisomerase ii defects.
      Title: A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: four genes involved in error-free DNA repair.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombinase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of rDNA IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in recombinational repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in recombinational repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Shu complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Shu complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in site of double-strand break IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Shu1p
    NP_011857.2
    • Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu2, and promotes error-free DNA repair, mediates inhibition of Srs2p function; essential for promoting the establishment of homolog bias during meiotic homologous recombination; promotes both crossover (CO) and non-crossover (NCO) pathways of meiotic recombination and formation of Rad51p filaments

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      98343..98795 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179086.1 → NP_011857.2  TPA: Shu1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011857.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKQ9, P38751, Q07190
      UniProtKB/TrEMBL
      G2WF61
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38751.2

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