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    pst3 SIN3 family co-repressor, Clr6 and Rpd3L histone deacetylase complex subunit Pst3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539793, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pst3
    Official Full Name
    SIN3 family co-repressor, Clr6 and Rpd3L histone deacetylase complex subunit Pst3
    Primary source
    PomBase:SPBC1734.16c
    Locus tag
    SPOM_SPBC1734.16C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pst3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (1089163..1094741, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cyclin-dependent protein kinase regulatory subunit Suc1 Neighboring gene RSC complex bromodomain subunit Rsc4 Neighboring gene ncRNA Neighboring gene chitin synthase-like protein 2 Neighboring gene ncRNA Neighboring gene valine--tRNA (Val) ligase Vrs1/Vas1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two assembly modes for SIN3 histone deacetylase complexes. Wang C, et al. Cell Discov, 2023 Apr 19. PMID 37076472, Free PMC Article
    2. A novel histone deacetylase complex in the control of transcription and genome stability. Zilio N, et al. Mol Cell Biol, 2014 Sep 15. PMID 25002536, Free PMC Article
    3. Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Shevchenko A, et al. Genome Biol, 2008. PMID 19040720, Free PMC Article
    4. Systematic analysis reveals the prevalence and principles of bypassable gene essentiality. Li J, et al. Nat Commun, 2019 Mar 1. PMID 30824696, Free PMC Article
    5. Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription. Heo DH, et al. Cell Rep, 2021 Sep 7. PMID 34496258, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of Rpd3L complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rpd3L-Expanded complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    SIN3 family co-repressor, Clr6 and Rpd3L histone deacetylase complex subunit Pst3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1089163..1094741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021341.3 → NP_595433.1  SIN3 family co-repressor, Clr6 and Rpd3L histone deacetylase complex subunit Pst3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595433.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74755
      Conserved Domains (4) summary
      smart00761
      Location:492 → 592
      HDAC_interact; Histone deacetylase (HDAC) interacting
      COG5602
      Location:1 → 1152
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]
      pfam02671
      Location:134 → 178
      PAH; Paired amphipathic helix repeat
      pfam16879
      Location:846 → 1096
      Sin3a_C; C-terminal domain of Sin3a protein
    Nucleotide Protein
    Heading Accession and Version

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