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    gpa2 heterotrimeric G protein alpha-2 subunit Gpa2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541720, updated on 18-Sep-2024

    Summary

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    Official Symbol
    gpa2
    Official Full Name
    heterotrimeric G protein alpha-2 subunit Gpa2
    Primary source
    PomBase:SPAC23H3.13c
    Locus tag
    SPOM_SPAC23H3.13C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    git8
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    Genomic context

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    See gpa2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (2516053..2519239, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene glucosidase Neighboring gene ncRNA Neighboring gene hydrogen/potassium transport protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LAlv9 family protein Neighboring gene protein Ddr48

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe. Hoffman CS. Biochem Soc Trans, 2005 Feb. PMID 15667320, Free PMC Article
    2. Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition. Isshiki T, et al. Genes Dev, 1992 Dec. PMID 1340462
    3. The fission yeast git5 gene encodes a Gbeta subunit required for glucose-triggered adenylate cyclase activation. Landry S, et al. Genetics, 2000 Apr. PMID 10747045, Free PMC Article
    4. Direct activation of fission yeast adenylyl cyclase by heterotrimeric G protein gpa2. Ogihara H, et al. Kobe J Med Sci, 2004. PMID 15925945
    5. Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway. Ivey FD, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15831585, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biochemical characterization of three activated Gpa2 proteins demonstrated an increased GDP-GTP exchange rate that would explain the mechanism of activation.
      Title: Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.
    2. gpa2 exhibits a direct and GTP-dependent binding to the Ras-associating domain (RAD) of cyr1
      Title: Direct activation of fission yeast adenylyl cyclase by heterotrimeric G protein gpa2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate cyclase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of induction of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    heterotrimeric G protein alpha-2 subunit Gpa2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2516053..2519239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019232.3 → NP_593803.1  heterotrimeric G protein alpha-2 subunit Gpa2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593803.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q04665
      Conserved Domains (2) summary
      cd00066
      Location:35 → 348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
      smart00275
      Location:14 → 352
      G_alpha; G protein alpha subunit
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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