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    met17 homocysteine synthase Met17 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540849, updated on 14-Nov-2024

    Summary

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    Official Symbol
    met17
    Official Full Name
    homocysteine synthase Met17
    Primary source
    PomBase:SPBC428.11
    Locus tag
    SPOM_SPBC428.11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cys2
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    Genomic context

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    See met17 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (465380..467247)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene 5S ribosomal RNA Neighboring gene ncRNA Neighboring gene peptidyl-prolyl cis-trans isomerase E Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sulphur amino acid synthesis in Schizosaccharomyces pombe represents a specific variant of sulphur metabolism in fungi. Brzywczy J, et al. Yeast, 2002 Jan 15. PMID 11754480
    2. O-Acetylhomoserine sulfhydrylase of the fission yeast Schizosaccharomyces pombe: partial purification, characterization, and its probable role in homocysteine biosynthesis. Yamagata S. J Biochem, 1984 Nov. PMID 6526818
    3. Multiple fungal enzymes possess cysteine synthase activity in vitro. Brzywczy J, et al. Res Microbiol, 2007 Jun. PMID 17482430
    4. Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts. Anver S, et al. EMBO Rep, 2014 Aug. PMID 24957674, Free PMC Article
    5. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables O-acetylhomoserine sulfhydrylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables O-acetylhomoserine sulfhydrylase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cysteine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cysteine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' L-methionine biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in L-homocysteine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-homocysteine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cysteine biosynthetic process from serine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteine biosynthetic process via cystathionine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    homocysteine synthase Met17

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      465380..467247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021096.3 → NP_595189.1  homocysteine synthase Met17 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595189.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13326
      Conserved Domains (2) summary
      PRK08776
      Location:7 → 429
      PRK08776; cystathionine gamma-synthase; Provisional
      TIGR01326
      Location:7 → 427
      OAH_OAS_sulfhy; OAH/OAS sulfhydrylase
    Nucleotide Protein
    Heading Accession and Version

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