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    sec61 translocon alpha subunit Sec61 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541037, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sec61
    Official Full Name
    translocon alpha subunit Sec61
    Primary source
    PomBase:SPBC354.02c
    Locus tag
    SPOM_SPBC354.02C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See sec61 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003423.3 (544751..547014, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tail anchored plasma membrane protein Uvi15 Neighboring gene protein Cut12 Neighboring gene ncRNA Neighboring gene GTP-binding protein Gtp1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Set1C complex WD repeat protein Swd3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning of SEC61 homologues from Schizosaccharomyces pombe and Yarrowia lipolytica reveals the extent of functional conservation within this core component of the ER translocation machinery. Broughton J, et al. J Cell Sci, 1997 Nov. PMID 9427389
    2. Calnexin is essential for survival under nitrogen starvation and stationary phase in Schizosaccharomyces pombe. Núñez A, et al. PLoS One, 2015. PMID 25803873, Free PMC Article
    3. An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin. Tange Y, et al. J Cell Sci, 2002 Nov 15. PMID 12376568
    4. High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library. Varberg JM, et al. G3 (Bethesda), 2020 Dec 3. PMID 33109728, Free PMC Article
    5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signal sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into ER membrane IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translocon alpha subunit Sec61

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      544751..547014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021132.3 → NP_595226.1  translocon alpha subunit Sec61 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595226.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P79088, Q9UU67
      Conserved Domains (3) summary
      PTZ00219
      Location:5 → 473
      PTZ00219; Sec61 alpha subunit; Provisional
      pfam00344
      Location:76 → 458
      SecY; SecY translocase
      pfam10559
      Location:41 → 74
      Plug_translocon; Plug domain of Sec61p
    Nucleotide Protein
    Heading Accession and Version

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