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    SHE4 She4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854200, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SHE4
    Official Full Name
    She4p
    Primary source
    SGD:S000005561
    Locus tag
    YOR035C
    See related
    AllianceGenome:SGD:S000005561; FungiDB:YOR035C; VEuPathDB:YOR035C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DIM1
    Summary
    Enables myosin binding activity. Involved in intracellular mRNA localization and mating type switching. Located in cytoplasm. Human ortholog(s) of this gene implicated in cataract 43 and myofibrillar myopathy 11. Orthologous to several human genes including UNC45B (unc-45 myosin chaperone B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SHE4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (397735..400104, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative palmitoyltransferase AKR2 Neighboring gene uncharacterized protein Neighboring gene SNAP receptor PEP12 Neighboring gene oxidoreductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding region. Shi H, et al. Proc Natl Acad Sci U S A, 2010 Dec 14. PMID 21115842, Free PMC Article
    2. UCS protein function is partially restored in the Saccharomyces cerevisiae she4 mutant with expression of the human UNC45-GC, but not UNC45-SM. Escalante SG, et al. Cell Stress Chaperones, 2018 Jul. PMID 29288355, Free PMC Article
    3. Localization of ASH1 mRNA particles in living yeast. Bertrand E, et al. Mol Cell, 1998 Oct. PMID 9809065
    4. Yeast UCS proteins promote actomyosin interactions and limit myosin turnover in cells. Lord M, et al. Proc Natl Acad Sci U S A, 2008 Jun 10. PMID 18523008, Free PMC Article
    5. The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p. Takizawa PA, et al. Proc Natl Acad Sci U S A, 2000 May 9. PMID 10792032, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that a UCS dimer in She4 links two myosins at their motor domains and thereby functions as one of the determinants for step size of myosin on actin filaments.
      Title: UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding region.
    2. UCS proteins promote myosin stability and interactions with actin.
      Title: Yeast UCS proteins promote actomyosin interactions and limit myosin turnover in cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating type switching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    She4p
    NP_014678.1
    • Protein containing a UCS (UNC-45/CRO1/SHE4) domain; binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      397735..400104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183454.1 → NP_014678.1  TPA: She4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014678.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2A2, P51534
      UniProtKB/TrEMBL
      B3LJ88
      Conserved Domains (1) summary
      pfam11701
      Location:167 → 316
      UNC45-central; Myosin-binding striated muscle assembly central
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51534.2

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