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    mae2 malate dehydrogenase Mae2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539592, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mae2
    Official Full Name
    malate dehydrogenase Mae2
    Primary source
    PomBase:SPCC794.12c
    Locus tag
    SPOM_SPCC794.12C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mae2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (275261..277262, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene UTP-glucose-1-phosphate uridylyltransferase Neighboring gene ncRNA Neighboring gene ENTH/VHS domain-containing protein Ent3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene transmembrane transporter Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Factors involved in the regulation of the Schizosaccharomyces pombe malic enzyme gene. Groenewald M, et al. Curr Genet, 2001 Jun. PMID 11453251
    2. Transcriptional regulation of the Schizosaccharomyces pombe malic enzyme gene, mae2. Viljoen M, et al. J Biol Chem, 1999 Apr 9. PMID 10187772
    3. Mutation of Gly-444 inactivates the S. pombe malic enzyme. Viljoen M, et al. FEMS Microbiol Lett, 1998 Oct 15. PMID 9809416
    4. The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring. Roberts-Galbraith RH, et al. J Cell Biol, 2009 Jan 12. PMID 19139265, Free PMC Article
    5. Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase. Chen JS, et al. Mol Cell Proteomics, 2013 May. PMID 23297348, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables malate dehydrogenase (decarboxylating) (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxaloacetate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in malate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    malate dehydrogenase Mae2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      275261..277262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022753.3 → NP_587760.1  malate dehydrogenase Mae2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587760.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A1EGU1, P40375
      Conserved Domains (3) summary
      cd05312
      Location:273 → 559
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PRK13529
      Location:1 → 565
      PRK13529; malate dehydrogenase; Provisional
      pfam00390
      Location:82 → 263
      malic; Malic enzyme, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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