PEX4 E2 ubiquitin-protein ligase peroxin 4 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PEX4
Official Full Name: E2 ubiquitin-protein ligase peroxin 4
Primary source: SGD:S000003365
Locus tag: YGR133W
See related: AllianceGenome:SGD:S000003365; FungiDB:YGR133W; VEuPathDB:YGR133W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PAS2; UBC10
Summary: Enables ubiquitin-protein transferase activity. Involved in protein autoubiquitination; protein import into peroxisome matrix, receptor recycling; and protein monoubiquitination. Located in peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor (Pex5).
Title: The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor.
The Pex4p:Pex22p assembly, and not Pex4p alone, functions as the E2 enzyme required for Pex5p ubiquitination. This is a novel mechanism of E2 enzyme regulation.
Title: Insights into ubiquitin-conjugating enzyme/ co-activator interactions from the structure of the Pex4p:Pex22p complex.
Pex4p-dependent ubiquitination of Pex5p occurs on a cysteine residue
Title: A conserved cysteine is essential for Pex4p-dependent ubiquitination of the peroxisomal import receptor Pex5p.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in peroxisome organization	IEA Inferred from Electronic Annotation more info
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into peroxisome matrix, receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein monoubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

NP_011649.1

Peroxisomal ubiquitin conjugating enzyme; required for peroxisomal matrix protein import and peroxisome biogenesis

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The following sections contain reference sequences that belong to a specific genome build. Explain