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    leu1 3-isopropylmalate dehydrogenase Leu1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540283, updated on 18-Sep-2024

    Summary

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    Official Symbol
    leu1
    Official Full Name
    3-isopropylmalate dehydrogenase Leu1
    Primary source
    PomBase:SPBC1A4.02c
    Locus tag
    SPOM_SPBC1A4.02C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPBC1E8.07c
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    Genomic context

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    See leu1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1974390..1975674, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein knh4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene anaphase-promoting complex substrate recognition subunit Apc10 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA topoisomerase II

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The primary structure of the leu1+ gene of Schizosaccharomyces pombe. Kikuchi Y, et al. Curr Genet, 1988 Oct. PMID 3063400
    2. Actin assembly requirements of the formin Fus1 to build the fusion focus. Billault-Chaumartin I, et al. J Cell Sci, 2022 Jul 1. PMID 35673994, Free PMC Article
    3. The SHR3 homologue from S. pombe demonstrates a conserved function of ER packaging chaperones. Martínez P, et al. J Cell Sci, 2000 Dec. PMID 11069779
    4. Multiple fungal enzymes possess cysteine synthase activity in vitro. Brzywczy J, et al. Res Microbiol, 2007 Jun. PMID 17482430
    5. Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin. Weisman R, et al. Genetics, 2005 Feb. PMID 15466417, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 3-isopropylmalate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-isopropylmalate dehydrogenase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-leucine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-isopropylmalate dehydrogenase Leu1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1974390..1975674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021706.4 → NP_595804.2  3-isopropylmalate dehydrogenase Leu1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595804.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P18869, Q76PD7
      Conserved Domains (1) summary
      TIGR00169
      Location:5 → 367
      leuB; 3-isopropylmalate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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