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    mad1 mitotic spindle checkpoint protein Mad1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540320, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mad1
    Official Full Name
    mitotic spindle checkpoint protein Mad1
    Primary source
    PomBase:SPBC3D6.04c
    Locus tag
    SPOM_SPBC3D6.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See mad1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (1274839..1277073, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 3'-tRNA-processing endonuclease Trz2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS25 Neighboring gene ncRNA Neighboring gene phosphatidate cytidylyltransferase Ptp4 Neighboring gene ribose-phosphate pyrophosphokinase Prs5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of localization of a spindle checkpoint protein, Mad2, in fission yeast. Ikui AE, et al. J Cell Sci, 2002 Apr 15. PMID 11950879
    2. Deletion of Mia1/Alp7 activates Mad2-dependent spindle assembly checkpoint in fission yeast. Sato M, et al. Nat Cell Biol, 2003 Sep. PMID 12951601
    3. Determinants of robustness in spindle assembly checkpoint signalling. Heinrich S, et al. Nat Cell Biol, 2013 Nov. PMID 24161933
    4. The Bub1-TPR Domain Interacts Directly with Mad3 to Generate Robust Spindle Checkpoint Arrest. Leontiou I, et al. Curr Biol, 2019 Jul 22. PMID 31257143, Free PMC Article
    5. The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint. Asakawa K, et al. Mol Biol Cell, 2006 Mar. PMID 16394105, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mad1 is the conserved dual-function protein acting in the spindle assembly checkpoint activation and chromosome gliding.
      Title: Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore.
    2. Mad1 potentially in conjunction with Bub1 has a crucial role in checkpoint signalling in addition to presenting Mad2.
      Title: Mad1 contribution to spindle assembly checkpoint signalling goes beyond presenting Mad2 at kinetochores.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables kinetochore adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule plus-end directed mitotic chromosome migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    mitotic spindle checkpoint protein Mad1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1274839..1277073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021425.3 → NP_595516.2  mitotic spindle checkpoint protein Mad1 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P87169
      UniProtKB/TrEMBL
      A0AAN2L3A6
    Nucleotide Protein
    Heading Accession and Version

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