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    tcb2 tricalbin, C2 domain protein (phospholipid binding) ER-plasma membrane tethering protein Tcb2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539477, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tcb2
    Official Full Name
    tricalbin, C2 domain protein (phospholipid binding) ER-plasma membrane tethering protein Tcb2
    Primary source
    PomBase:SPCP31B10.06
    Locus tag
    SPOM_SPCP31B10.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mug190
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    Genomic context

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    See tcb2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (532657..537202)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tyrosyl-DNA phosphodiesterase Tdp1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene translation elongation factor 2 eft202 Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL33

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of hsp16 in response to nucleotide depletion is regulated via the spc1 MAPK pathway in Schizosaccharomyces pombe. Taricani L, et al. Nucleic Acids Res, 2001 Jul 15. PMID 11452028, Free PMC Article
    2. Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries. Wang J, et al. Genes Dev, 2013 Sep 1. PMID 24013502, Free PMC Article
    3. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
    4. Transcription and RNA-processing in fission yeast mitochondria. Schäfer B, et al. RNA, 2005 May. PMID 15811919, Free PMC Article
    5. The genome sequence of Schizosaccharomyces pombe. Wood V, et al. Nature, 2002 Feb 21. PMID 11859360

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables phospholipid binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein-membrane adaptor activity IC
    Inferred by Curator
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum-plasma membrane tethering ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cortical endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in endoplasmic reticulum HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tricalbin, C2 domain protein (phospholipid binding) ER-plasma membrane tethering protein Tcb2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      532657..537202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022855.3 → NP_587862.1  tricalbin, C2 domain protein (phospholipid binding) ER-plasma membrane tethering protein Tcb2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587862.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9USG8
      Conserved Domains (3) summary
      cd04041
      Location:469 → 578
      C2A_fungal; C2 domain first repeat; fungal group
      cd04052
      Location:693 → 801
      C2B_Tricalbin-like; C2 domain second repeat present in Tricalbin-like proteins
      COG5038
      Location:7 → 1188
      COG5038; Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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