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    putative metalloendopeptidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854698, updated on 9-Dec-2024

    Summary

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    Official Full Name
    putative metalloendopeptidase
    Primary source
    SGD:S000001370
    Locus tag
    YIL108W
    See related
    AllianceGenome:SGD:S000001370; FungiDB:YIL108W; VEuPathDB:YIL108W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable metallopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (160887..162977)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene protein-histidine N-methyltransferase Neighboring gene COPII subunit SEC24 Neighboring gene 6-phosphofructo-2-kinase Neighboring gene Mob1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhanced peptide secretion by gene disruption of CYM1, a novel protease in Saccharomyces cerevisiae. Jønson L, et al. Eur J Biochem, 2004 Dec. PMID 15606766
    2. Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation. Sanchez A, et al. Proc Natl Acad Sci U S A, 2020 Dec 1. PMID 33199619, Free PMC Article
    3. The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae. Josefson R, et al. Sci Rep, 2023 Jun 7. PMID 37286562, Free PMC Article
    4. A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules. Tong AH, et al. Science, 2002 Jan 11. PMID 11743162
    5. Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis. Wild P, et al. Mol Cell, 2019 Aug 22. PMID 31351878, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative metalloendopeptidase
    NP_012158.1
    • Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      160887..162977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179456.1 → NP_012158.1  TPA: putative metalloendopeptidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012158.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVH9, P40483, Q6B2N8
      UniProtKB/TrEMBL
      B3LTV5, C7GKN4, C8ZAD7, G2WG44, N1P2G6
      Conserved Domains (2) summary
      cd09613
      Location:533 → 694
      Jacalin_metallopeptidase_like; Jacalin-like lectin domain of putative metalloproteases and similar proteins
      pfam12044
      Location:7 → 430
      Metallopep; Putative peptidase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40483.1

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