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    THI6 bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    THI6
    Official Full Name
    bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase
    Primary source
    SGD:S000006135
    Locus tag
    YPL214C
    See related
    AllianceGenome:SGD:S000006135; FungiDB:YPL214C; VEuPathDB:YPL214C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables hydroxyethylthiazole kinase activity and thiamine-phosphate diphosphorylase activity. Involved in thiamine biosynthetic process. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See THI6 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (148569..150191, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cbp3p Neighboring gene U2 snRNP complex subunit LEA1 Neighboring gene pseudouridine synthase PUS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the THI6 gene encoding a bifunctional thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase from Saccharomyces cerevisiae. Nosaka K, et al. J Biol Chem, 1994 Dec 2. PMID 7982968
    2. Transcriptome analysis reveals the protection mechanism of proanthocyanidins for Saccharomyces cerevisiae during wine fermentation. Li J, et al. Sci Rep, 2020 Apr 21. PMID 32317674, Free PMC Article
    3. Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mojzita D, et al. Mol Genet Genomics, 2006 Aug. PMID 16850348
    4. A novel single-cell screening platform reveals proteome plasticity during yeast stress responses. Breker M, et al. J Cell Biol, 2013 Mar 18. PMID 23509072, Free PMC Article
    5. Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation. Sanchez A, et al. Proc Natl Acad Sci U S A, 2020 Dec 1. PMID 33199619, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyethylthiazole kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyethylthiazole kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine-phosphate diphosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine-phosphate diphosphorylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine-phosphate diphosphorylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in thiamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase
    NP_015110.1
    • Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      148569..150191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184028.1 → NP_015110.1  TPA: bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015110.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3F6, P41835
      UniProtKB/TrEMBL
      A6ZW41, B3LKL6, C7GN41, C8ZIG5, G2WNX1, N1NW91
      Conserved Domains (2) summary
      TIGR00694
      Location:255 → 529
      thiM; hydroxyethylthiazole kinase
      TIGR00693
      Location:11 → 225
      thiE; thiamine-phosphate diphosphorylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41835.1

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