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    RGT2 glucose sensor [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851417, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RGT2
    Official Full Name
    glucose sensor
    Primary source
    SGD:S000002297
    Locus tag
    YDL138W
    See related
    AllianceGenome:SGD:S000002297; FungiDB:YDL138W; VEuPathDB:YDL138W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-glucose binding activity. Involved in glucose mediated signaling pathway. Located in plasma membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RGT2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (213351..215642)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II core subunit RPO21 Neighboring gene Scm3p Neighboring gene Arf family GTPase ARF2 Neighboring gene ribosomal 60S subunit protein L35B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two glucose sensing/signaling pathways stimulate glucose-induced inactivation of maltose permease in Saccharomyces. Jiang H, et al. Mol Biol Cell, 1997 Jul. PMID 9243508, Free PMC Article
    2. Glucose regulation of the paralogous glucose sensing receptors Rgt2 and Snf3 of the yeast Saccharomyces cerevisiae. Kim JH, et al. Biochim Biophys Acta Gen Subj, 2021 Jun. PMID 33617932
    3. Glucose sensing and signaling by two glucose receptors in the yeast Saccharomyces cerevisiae. Ozcan S, et al. EMBO J, 1998 May 1. PMID 9564039, Free PMC Article
    4. Genetic Analysis of Signal Generation by the Rgt2 Glucose Sensor of Saccharomyces cerevisiae. Scharff-Poulsen P, et al. G3 (Bethesda), 2018 Jul 31. PMID 29954842, Free PMC Article
    5. Cellobiose Consumption Uncouples Extracellular Glucose Sensing and Glucose Metabolism in Saccharomyces cerevisiae. Chomvong K, et al. mBio, 2017 Aug 8. PMID 28790206, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Multiple roles for the cytoplasmic C-terminal domains of the yeast cell surface receptors Rgt2 and Snf3 in glucose sensing and signaling.
      Title: Multiple roles for the cytoplasmic C-terminal domains of the yeast cell surface receptors Rgt2 and Snf3 in glucose sensing and signaling.
    2. RGT2 constitutive mutations alter evolutionarily-conserved amino acids in the transmembrane spanning regions of Rgt2. They cause Rgt2 to adopt inward-facing or occluded conformations that generate the glucose signal.
      Title: Genetic Analysis of Signal Generation by the Rgt2 Glucose Sensor of Saccharomyces cerevisiae.
    3. Rgt2 and Snf3 glucose sensors are primary targets of methylglyoxal, which causes degradation of the Rgt2 and Snf3.
      Title: The glucose metabolite methylglyoxal inhibits expression of the glucose transporter genes by inactivating the cell surface glucose sensors Rgt2 and Snf3 in yeast.
    4. Mth1 and Std1, which are downstream effectors of the Snf3/Rgt2 pathway, were required for viability through mitochondrial function but not fermentative metabolism
      Title: Disruption of Snf3/Rgt2 glucose sensors decreases lifespan and caloric restriction effectiveness through Mth1/Std1 by adjusting mitochondrial efficiency in yeast.
    5. RGT2-1 promotes ubiquitination and subsequent degradation of Mth1 and Std1 regardless of the presence of glucose.
      Title: Biochemical evidence for glucose-independent induction of HXT expression in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-glucose binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glucose sensor
    NP_010143.1
    • Plasma membrane high glucose sensor that regulates glucose transport; low affinity sesnor that contains 12 predicted transmembrane segments and a long C-terminal tail required for hexose transporter induction; phosphorylation of the tail by Yck1p/Yck2p facilitates binding to the HXT co-repressors, Mth1p and Std1p; RGT2 has a paralog, SNF3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      213351..215642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180198.1 → NP_010143.1  TPA: glucose sensor [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010143.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRL0, Q12300
      UniProtKB/TrEMBL
      G2WC23, N1P960
      Conserved Domains (1) summary
      TIGR00879
      Location:76 → 555
      SP; MFS transporter, sugar porter (SP) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12300.1

    Gene LinkOut

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