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    CST9 SUMO ligase CST9 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851110, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CST9
    Official Full Name
    SUMO ligase CST9
    Primary source
    SGD:S000004386
    Locus tag
    YLR394W
    See related
    AllianceGenome:SGD:S000004386; FungiDB:YLR394W; VEuPathDB:YLR394W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ZIP3
    Summary
    Enables SUMO transferase activity and chromatin binding activity. Involved in double-strand break repair via homologous recombination; meiosis I; and protein sumoylation. Located in condensed nuclear chromosome. Is active in chromosome, centromeric region and site of double-strand break. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CST9 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (907950..909398)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Art10p Neighboring gene Atp10p Neighboring gene cytochrome c oxidase subunit VIII Neighboring gene tethering complex ATP-binding subunit VPS33

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks. Henderson KA, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070750, Free PMC Article
    2. Imposition of crossover interference through the nonrandom distribution of synapsis initiation complexes. Fung JC, et al. Cell, 2004 Mar 19. PMID 15035982
    3. Meiotic prophase roles of Rec8 in crossover recombination and chromosome structure. Yoon SW, et al. Nucleic Acids Res, 2016 Nov 2. PMID 27484478, Free PMC Article
    4. Control of meiotic pairing and recombination by chromosomally tethered 26S proteasome. Ahuja JS, et al. Science, 2017 Jan 27. PMID 28059715, Free PMC Article
    5. The Arabidopsis HEI10 is a new ZMM protein related to Zip3. Chelysheva L, et al. PLoS Genet, 2012. PMID 22844245, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A tel1Delta mutant has globally increased amounts of Spo11-oligonucleotide complexes and altered Spo11-oligonucleotide lengths, consistent with conserved roles for Tel1 in control of DSB number and processing..We further find that effects of Tel1 are distinct but partially overlapping with previously described contributions of the recombination regulator Cst9 (also known as Zip3).
      Title: Numerical and spatial patterning of yeast meiotic DNA breaks by Tel1.
    2. proteolytic core and regulatory proteasome particles were recruited to chromosomes by Zip3, the ortholog of mammalian E3 ligase RNF212, and synaptonemal complex protein Zip1 .
      Title: Control of meiotic pairing and recombination by chromosomally tethered 26S proteasome.
    3. We show that Zip3 associates with DSB sites that are engaged in repair by CO, and Zip3 enrichment at DSBs reflects the DSB tendency to be repaired by CO.
      Title: Differential association of the conserved SUMO ligase Zip3 with meiotic double-strand break sites reveals regional variations in the outcome of meiotic recombination.
    4. Spo22 (also called Zip4) is identified as a probable functional collaborator of Zip2/3
      Title: Bioinformatic analyses implicate the collaborating meiotic crossover/chiasma proteins Zip2, Zip3, and Spo22/Zip4 in ubiquitin labeling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SUMO transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SUMO transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, centromeric region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in synaptonemal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptonemal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SUMO ligase CST9
    NP_013498.3
    • SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; associates with centromeres early in meiosis, then with chromosome axes and finally with double-strand break sites that are engaged in repair by crossovers; potential Cdc28p substrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      907950..909398
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182282.3 → NP_013498.3  TPA: SUMO ligase CST9 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013498.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ29, Q06032
      UniProtKB/TrEMBL
      A7A1R9, G2WJK9, N1P7B8
      Conserved Domains (1) summary
      pfam14634
      Location:54 → 92
      zf-RING_5; zinc-RING finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06032.1

    Gene LinkOut

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