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    PBP2 Pbp2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852533, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PBP2
    Official Full Name
    Pbp2p
    Primary source
    SGD:S000000437
    Locus tag
    YBR233W
    See related
    AllianceGenome:SGD:S000000437; FungiDB:YBR233W; VEuPathDB:YBR233W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HEK1
    Summary
    Enables mRNA binding activity. Involved in telomere maintenance. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to several human genes including PCBP2 (poly(rC) binding protein 2) and PCBP4 (poly(rC) binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PBP2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (683428..684669)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Swc5p Neighboring gene Dad3p Neighboring gene Arc40p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of hnRNP K protein-RNA interactions. Klimek-Tomczak K, et al. J Mol Biol, 2004 Sep 24. PMID 15351640
    2. Yeast hnRNP K-like genes are involved in regulation of the telomeric position effect and telomere length. Denisenko O, et al. Mol Cell Biol, 2002 Jan. PMID 11739741, Free PMC Article
    3. Identification of Saccharomyces cerevisiae genes conferring resistance to quinoline ring-containing antimalarial drugs. Delling U, et al. Antimicrob Agents Chemother, 1998 May. PMID 9593122, Free PMC Article
    4. Pbp1p, a factor interacting with Saccharomyces cerevisiae poly(A)-binding protein, regulates polyadenylation. Mangus DA, et al. Mol Cell Biol, 1998 Dec. PMID 9819425, Free PMC Article
    5. KH domain-containing proteins of yeast: absence of a fragile X gene homologue. Currie JR, et al. Am J Med Genet, 1999 May 28. PMID 10331606

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of RNA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pbp2p
    NP_009792.3
    • RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      683428..684669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178581.3 → NP_009792.3  TPA: Pbp2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009792.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQM8, P38151
      UniProtKB/TrEMBL
      A6ZLH1, B3LMT0, B5VEI2, C7GMS1, D3UEY0, G2W9N5, N1P730
      Conserved Domains (3) summary
      cd00105
      Location:334 → 394
      KH-I; K homology (KH) RNA-binding domain, type I
      cd22438
      Location:69 → 137
      KH-I_PCBP_rpt1; first type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs)
      cd22456
      Location:150 → 218
      KH-I_Rnc1_rpt2; second type I K homology (KH) RNA-binding domain found in Schizosaccharomyces pombe RNA-binding protein Rnc1 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38151.1

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