bgs1 primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: bgs1
Official Full Name: primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1
Primary source: PomBase:SPBC19G7.05c
Locus tag: SPOM_SPBC19G7.05C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: cps1; drc1; swl1
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Genomic context

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See bgs1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_003423.3 (2350922..2357364, complement)

Chromosome II - NC_003423.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003423.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bgs1 has a role in both the first septation phase where it is lost from the immature septum after F-actin removal, and in the second phase where the septum septum can maintain a Bgs1 ring and septum ingression without F-actin, but ingression becomes Cdc42 and exocyst dependent
Title: Two S. pombe septation phases differ in ingression rate, septum structure, and response to F-actin loss.
Findings suggest that septins act as key players in an accurate establishment and the maintenance of contractile actomyosin ring (CAR) by orchestrating the equatorial dynamics of separation initiation network kinase Sid2p (Sid2p) and glucan synthases Bgs1p and Ags1p.
Title: Septins regulate the equatorial dynamics of the separation initiation network kinase Sid2p and glucan synthases to ensure proper cytokinesis.
Sbg1 and Bgs1 physically interact and are interdependent for localization to the plasma membrane
Title: Sbg1 Is a Novel Regulator for the Localization of the β-Glucan Synthase Bgs1 in Fission Yeast.
Sbg1p and Bgs1p physically interact and are dependent on each other to localize to the division site. Loss of Sbg1p results in an unstable actomyosin ring that unravels and slides, leading to an inability to deposit a single contiguous division septum and an important reduction of the beta-1,3-glucan proportion in the cell wal
Title: A New Membrane Protein Sbg1 Links the Contractile Ring Apparatus and Septum Synthesis Machinery in Fission Yeast.
Findings reveal a role for Sip1 in the regulation of Golgi/endosome trafficking in coordination with the AP-1 complex, and identified Bgs1, required for cell wall synthesis, as the new cargo of AP-1-dependent trafficking.
Title: Sip1, a conserved AP-1 accessory protein, is important for Golgi/endosome trafficking in fission yeast.
cytokinesis machinery integrity under stress conditions requires the glucan synthase Bgs1p and its regulator Cfh3p
Title: The integrity of the cytokinesis machinery under stress conditions requires the glucan synthase Bgs1p and its regulator Cfh3p.
fission yeast SEL1 domain protein Cfh3p is a novel regulator of the glucan synthase Bgs1p whose function is more relevant under stress conditions
Title: The fission yeast SEL1 domain protein Cfh3p: a novel regulator of the glucan synthase Bgs1p whose function is more relevant under stress conditions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables 1,3-beta-D-glucan synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1,3-beta-D-glucan synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in (1->3)-beta-D-glucan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall (1->3)-beta-D-glucan biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in fungal-type cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungal-type cell wall polysaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fungal-type cell wall polysaccharide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic division septum assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary cell septum biogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of 1,3-beta-D-glucan synthase complex	IC Inferred by Curator more info	PubMed
is_active_in cell cortex of cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell cortex of growing cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell division site	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
is_active_in division septum	IDA Inferred from Direct Assay more info	PubMed
is_active_in fungal-type cell wall	IDA Inferred from Direct Assay more info	PubMed
is_active_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in old growing cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003423.3 Reference assembly

Range

2350922..2357364 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001021879.3 → NP_595971.1 primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_595971.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q10287

Conserved Domains (2) summary

pfam02364
Location:693 → 1508

Glucan_synthase; 1,3-beta-glucan synthase component

pfam14288
Location:186 → 292

FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1