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    AVT1 Avt1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853457, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AVT1
    Official Full Name
    Avt1p
    Primary source
    SGD:S000003761
    Locus tag
    YJR001W
    See related
    AllianceGenome:SGD:S000003761; FungiDB:YJR001W; VEuPathDB:YJR001W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables L-glutamine transmembrane transporter activity; L-isoleucine transmembrane transporter activity; and L-tyrosine transmembrane transporter activity. Involved in amino acid transmembrane transport; proline transport; and vacuolar transport. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy and generalized epilepsy with febrile seizures plus. Orthologous to human SLC32A1 (solute carrier family 32 member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AVT1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (436802..438610)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 Neighboring gene proteasome core particle subunit beta 1 Neighboring gene rRNA-processing protein MPP10 Neighboring gene Mrx12p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A PQ-loop protein Ypq2 is involved in the exchange of arginine and histidine across the vacuolar membrane of Saccharomyces cerevisiae. Kawano-Kawada M, et al. Sci Rep, 2019 Oct 21. PMID 31636363, Free PMC Article
    2. Potassium restriction boosts vacuolar acidity and extends lifespan in yeast. Sasikumar AN, et al. Exp Gerontol, 2019 Jun. PMID 30742903, Free PMC Article
    3. Characterization of Avt1p as a vacuolar proton/amino acid antiporter in Saccharomyces cerevisiae. Tone J, et al. Biosci Biotechnol Biochem, 2015. PMID 25747199
    4. A vacuolar membrane protein Avt7p is involved in transport of amino acid and spore formation in Saccharomyces cerevisiae. Tone J, et al. Biosci Biotechnol Biochem, 2015. PMID 25266154
    5. Ypq3p-dependent histidine uptake by the vacuolar membrane vesicles of Saccharomyces cerevisiae. Manabe K, et al. Biosci Biotechnol Biochem, 2016 Jun. PMID 26928127

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Avt1 protein is a proton/amino acid antiporter important for vacuolar compartmentalization of various amino acids.
      Title: Characterization of Avt1p as a vacuolar proton/amino acid antiporter in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-glutamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-isoleucine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables L-tyrosine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in branched-chain amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proline transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tyrosine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Avt1p
    NP_012534.1
    • Vacuolar transporter; imports large neutral amino acids into vacuole; targeted to vacuole via AP-3 pathway; member of family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      436802..438610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181658.1 → NP_012534.1  TPA: Avt1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012534.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWH5, P47082
      UniProtKB/TrEMBL
      A6ZPW7, B3LQ99, C7GUT9, D3UF69, G2WH10, N1NZZ6
      Conserved Domains (1) summary
      pfam01490
      Location:206 → 601
      Aa_trans; Transmembrane amino acid transporter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47082.1

    Gene LinkOut

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