U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    myh1 DNA adenine glycosylase Myh1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542727, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    myh1
    Official Full Name
    DNA adenine glycosylase Myh1
    Primary source
    PomBase:SPAC26A3.02
    Locus tag
    SPOM_SPAC26A3.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    myh
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See myh1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (3334882..3337714)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene U3 snoRNP-associated protein Rrp9 Neighboring gene ncRNA Neighboring gene aspartic protease Sxa1 Neighboring gene RecQ mediated genome instability protein Rmi1 Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL20

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Shizosaccharomyces pombe homolog (SpMYH) of the Escherichia coli MutY is required for removal of guanine from 8-oxoguanine/guanine mispairs to prevent G:C to C:G transversions. Doi T, et al. J Radiat Res, 2005 Jun. PMID 15988139
    2. Fission yeast (Schizosaccharomyces pombe) cells defective in the MutY-homologous glycosylase activity have a mutator phenotype and are sensitive to hydrogen peroxide. Chang DY, et al. Mol Genet Genomics, 2001 Oct. PMID 11683277
    3. Characterization of the recombinant MutY homolog, an adenine DNA glycosylase, from yeast Schizosaccharomyces pombe. Lu AL, et al. J Biol Chem, 1998 Sep 25. PMID 9737967
    4. A role for Myh1 in DNA repair after treatment with strand-breaking and crosslinking chemotherapeutic agents. Jansson K, et al. Environ Mol Mutagen, 2013 Jun. PMID 23677513
    5. The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombe. Chang DY, et al. J Mol Biol, 2011 Jan 21. PMID 21110984, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thus, Myh1 and Apn2 constitute an initial base excision complex in Schizosaccharomyces pombe.
      Title: Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeast.
    2. These results suggest that SpMyh1 repair regulates the functions of SpHst4 and the 9-1-1 complex in maintaining genomic stability.
      Title: The role of MutY homolog (Myh1) in controlling the histone deacetylase Hst4 in the fission yeast Schizosaccharomyces pombe.
    3. myh1 mutation confers a moderately increased UV sensitivity alone and in combination with mutations in several DNA repair genes.
      Title: The tumor suppressor homolog in fission yeast, myh1(+), displays a strong interaction with the checkpoint gene rad1(+).
    4. MYH may act as an adaptor to recruit checkpoint proteins to the DNA lesions
      Title: Interaction of checkpoint proteins Hus1/Rad1/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenine/guanine mispair binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine/guanine mispair binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidized purine DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidized purine DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables purine-specific mismatch base pair DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables purine-specific mismatch base pair DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables purine-specific mismatch base pair DNA N-glycosylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in base-excision repair EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair, AP site formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in depurination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA adenine glycosylase Myh1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3334882..3337714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019569.3 → NP_594145.1  DNA adenine glycosylase Myh1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594145.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74679, Q10159
      Conserved Domains (4) summary
      smart00525
      Location:225 → 245
      FES; iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)
      COG1194
      Location:17 → 419
      MutY; Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]
      cd00056
      Location:63 → 222
      ENDO3c; endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases
      cd03431
      Location:297 → 430
      DNA_Glycosylase_C; DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous