FDH1 formate dehydrogenase (NAD+) [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FDH1
Official Full Name: formate dehydrogenase (NAD+)
Primary source: SGD:S000005915
Locus tag: YOR388C
See related: AllianceGenome:SGD:S000005915; FungiDB:YOR388C; VEuPathDB:YOR388C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables formate dehydrogenase (NAD+) activity. Involved in formate catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FDH1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (1071793..1072923, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables formate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables formate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables formate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in formate catabolic process	IEA Inferred from Electronic Annotation more info
involved_in formate catabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: formate dehydrogenase (NAD+)

NP_015033.1

EC 1.17.1.9

NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

1071793..1072923 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183808.1 → NP_015033.1 TPA: formate dehydrogenase (NAD+) [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015033.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZN46, C8ZHD6, D6W381, N1P3Y5, P0CT22, Q08911

UniProtKB/TrEMBL

G2WNP8

Conserved Domains (1) summary

cd05302
Location:4 → 371

FDH; NAD-dependent Formate Dehydrogenase (FDH)