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    lac1 sphingosine N-acyltransferase Lac1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540466, updated on 14-Nov-2024

    Summary

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    Official Symbol
    lac1
    Official Full Name
    sphingosine N-acyltransferase Lac1
    Primary source
    PomBase:SPBC3E7.15c
    Locus tag
    SPOM_SPBC3E7.15C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mug83; SPBC4F6.02c
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    Genomic context

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    See lac1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (2684885..2688011, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene chitin synthase regulatory factor Neighboring gene ncRNA Neighboring gene SYF2 family splicing factor syf2 Neighboring gene Sm snRNP core protein Smf1 Neighboring gene ncRNA Neighboring gene 2-isopropylmalate synthase Leu3 Neighboring gene 60S ribosomal protein uL23

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Ceramide Synthase Subunit Lac1 Regulates Cell Growth and Size in Fission Yeast. Flor-Parra I, et al. Int J Mol Sci, 2021 Dec 28. PMID 35008733, Free PMC Article
    2. Loss of regulators of vacuolar ATPase function and ceramide synthesis results in multidrug sensitivity in Schizosaccharomyces pombe. Dawson K, et al. Eukaryot Cell, 2008 Jun. PMID 18441123, Free PMC Article
    3. Global coordination of transcriptional control and mRNA decay during cellular differentiation. Amorim MJ, et al. Mol Syst Biol, 2010 Jun 8. PMID 20531409, Free PMC Article
    4. Systematic analysis reveals the prevalence and principles of bypassable gene essentiality. Li J, et al. Nat Commun, 2019 Mar 1. PMID 30824696, Free PMC Article
    5. High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library. Varberg JM, et al. G3 (Bethesda), 2020 Dec 3. PMID 33109728, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of S. pombe lac1 results in heat shock sensitivity and disruption of plasma membrane sterol distribution.
      Title: Loss of regulators of vacuolar ATPase function and ceramide synthesis results in multidrug sensitivity in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    sphingosine N-acyltransferase Lac1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2684885..2688011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022018.3 → NP_596102.1  sphingosine N-acyltransferase Lac1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596102.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O59735
      Conserved Domains (3) summary
      COG5058
      Location:1 → 384
      LAG1; Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor [Intracellular trafficking and secretion]
      pfam03798
      Location:145 → 350
      TRAM_LAG1_CLN8; TLC domain
      pfam08390
      Location:85 → 138
      TRAM1; TRAM1-like protein
    Nucleotide Protein
    Heading Accession and Version

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