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    NRE1 sepiapterin reductase family protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NRE1
    Official Full Name
    sepiapterin reductase family protein
    Primary source
    SGD:S000001474
    Locus tag
    YIR035C
    See related
    AllianceGenome:SGD:S000001474; FungiDB:YIR035C; VEuPathDB:YIR035C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables benzil reductase [(S)-benzoin-forming] activity. Located in cytoplasm. Human ortholog(s) of this gene implicated in cortisone reductase deficiency (multiple); hypertension (multiple); and type 2 diabetes mellitus. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NRE1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (421026..421790, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Mga2p Neighboring gene saccharopine dehydrogenase (NAD+, L-lysine-forming) Neighboring gene sepiapterin reductase family protein IRC24 Neighboring gene peroxiredoxin HYR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae NRE1 and IRC24 Encode Paralogous Benzil Oxidoreductases. Garcia B, et al. MicroPubl Biol, 2023. PMID 37602278, Free PMC Article
    2. Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability. Strome ED, et al. Genetics, 2008 Mar. PMID 18245329, Free PMC Article
    3. The nucleotide sequence of Saccharomyces cerevisiae chromosome IX. Churcher C, et al. Nature, 1997 May 29. PMID 9169870
    4. Subcellular localization of the yeast proteome. Kumar A, et al. Genes Dev, 2002 Mar 15. PMID 11914276, Free PMC Article
    5. The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range. Girstmair H, et al. Nat Commun, 2019 Aug 9. PMID 31399574, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables benzil reductase [(S)-benzoin-forming] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    sepiapterin reductase family protein
    NP_012301.3
    • Benzil oxidoreductase with preference for NADPH; localizes to the cytoplasm; sequence similarity with short-chain dehydrogenase/reductases; putative paralog of IRC24

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      421026..421790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179557.3 → NP_012301.3  TPA: sepiapterin reductase family protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012301.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVW6, P40579
      UniProtKB/TrEMBL
      B5VKX2, C7GLS1, G2WFW3, N1P2C7
      Conserved Domains (1) summary
      cd05367
      Location:4 → 246
      SPR-like_SDR_c; sepiapterin reductase (SPR)-like, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40579.1

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