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    VPS70 putative zinc metalloprotease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853590, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS70
    Official Full Name
    putative zinc metalloprotease
    Primary source
    SGD:S000003887
    Locus tag
    YJR126C
    See related
    AllianceGenome:SGD:S000003887; FungiDB:YJR126C; VEuPathDB:YJR126C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable carboxypeptidase activity. Involved in protein targeting to vacuole. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; cerebral infarction; hemochromatosis (multiple); immunodeficiency 46; and multiple myeloma. Orthologous to several human genes including NAALAD2 (N-acetylated alpha-linked acidic dipeptidase 2); NAALADL1 (N-acetylated alpha-linked acidic dipeptidase like 1); and FOLH1 (folate hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS70 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (656254..658689, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ent3p Neighboring gene Rsf2p Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improved linkage analysis of Quantitative Trait Loci using bulk segregants unveils a novel determinant of high ethanol tolerance in yeast. Duitama J, et al. BMC Genomics, 2014 Mar 19. PMID 24640961, Free PMC Article
    2. Adaptation to High Ethanol Reveals Complex Evolutionary Pathways. Voordeckers K, et al. PLoS Genet, 2015 Nov. PMID 26545090, Free PMC Article
    3. Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction. Matsui T, et al. PLoS Genet, 2016 Jul. PMID 27437938, Free PMC Article
    4. Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Entian KD, et al. Mol Gen Genet, 1999 Dec. PMID 10628851
    5. Prevacuolar compartment morphology in vps mutants of Saccharomyces cerevisiae. Hedman JM, et al. Cell Biol Int, 2007 Oct. PMID 17543551

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein targeting to vacuole HMP PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative zinc metalloprotease
    NP_012660.1
    • hypothetical protein involved in vacuolar protein sorting; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      656254..658689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181784.1 → NP_012660.1  TPA: putative zinc metalloprotease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012660.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWU5, P47161
      UniProtKB/TrEMBL
      G2WHC9, N1P3P3
      Conserved Domains (4) summary
      cd02121
      Location:187 → 413
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd03874
      Location:419 → 649
      M28_PMSA_TfR_like; M28 Zn-peptidase Transferrin Receptor-like family
      pfam04253
      Location:731 → 799
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:135 → 187
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47161.1

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