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    pup1 proteasome core particle subunit beta 2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541805, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pup1
    Official Full Name
    proteasome core particle subunit beta 2
    Primary source
    PomBase:SPAC23D3.07
    Locus tag
    SPOM_SPAC23D3.07
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mts6
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    Genomic context

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    See pup1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (4350968..4352369)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene nucleoporin, WD repeat Nup146 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SWI/SNF and RSC complex subunit Arp42 Neighboring gene U1 snRNP-associated protein Usp108 Neighboring gene ncRNA Neighboring gene cell wall and ascospore endo-1,3-beta-glucanase Eng2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution. Bohn S, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21098295, Free PMC Article
    2. Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation. Xu X, et al. Proc Natl Acad Sci U S A, 2019 May 28. PMID 31072933, Free PMC Article
    3. The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast. Seo HD, et al. J Biol Chem, 2017 Oct 13. PMID 28784663, Free PMC Article
    4. Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes. Leitner A, et al. Proc Natl Acad Sci U S A, 2014 Jul 1. PMID 24938783, Free PMC Article
    5. Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast. Takeda K, et al. Proc Natl Acad Sci U S A, 2010 Feb 23. PMID 20133687, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome core particle subunit beta 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4350968..4352369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019973.3 → NP_594544.1  proteasome core particle subunit beta 2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594544.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09841
      Conserved Domains (3) summary
      COG0638
      Location:10 → 237
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03763
      Location:36 → 224
      proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
      pfam12465
      Location:228 → 253
      Pr_beta_C; Proteasome beta subunits C terminal
    Nucleotide Protein
    Heading Accession and Version

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