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    SYF2 Syf2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853030, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SYF2
    Official Full Name
    Syf2p
    Primary source
    SGD:S000003361
    Locus tag
    YGR129W
    See related
    AllianceGenome:SGD:S000003361; FungiDB:YGR129W; VEuPathDB:YGR129W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NTC31
    Summary
    Predicted to contribute to first spliceosomal transesterification activity and second spliceosomal transesterification activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nucleus. Part of Prp19 complex and U2-type spliceosomal complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SYF2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (750400..751047)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Utp8p Neighboring gene uncharacterized protein Neighboring gene Fhn1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint. Dahan O, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384582, Free PMC Article
    2. Functional analyses of interacting factors involved in both pre-mRNA splicing and cell cycle progression in Saccharomyces cerevisiae. Russell CS, et al. RNA, 2000 Nov. PMID 11105756, Free PMC Article
    3. The Prp19C/NTC subunit Syf2 and the Prp19C/NTC-associated protein Cwc15 function in TREX occupancy and transcription elongation. Henke-Schulz L, et al. RNA, 2024 Jun 17. PMID 38627018, Free PMC Article
    4. Functional and physical interactions between components of the Prp19p-associated complex. Chen CH, et al. Nucleic Acids Res, 2002 Feb 15. PMID 11842115, Free PMC Article
    5. Splicing factor Cwc22 is required for the function of Prp2 and for the spliceosome to escape from a futile pathway. Yeh TC, et al. Mol Cell Biol, 2011 Jan. PMID 20956557, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to first spliceosomal transesterification activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to second spliceosomal transesterification activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type catalytic step 1 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type post-mRNA release spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Syf2p
    NP_011645.3
    • Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      750400..751047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181258.3 → NP_011645.3  TPA: Syf2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011645.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUR1, P53277
      UniProtKB/TrEMBL
      A6ZUE3, B3LI99, B5VJ75, C7GUG6, C8Z922, G2WEL1, N1P3R2
      Conserved Domains (1) summary
      pfam08231
      Location:60 → 209
      SYF2; SYF2 splicing factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53277.1

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