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    RPN13 proteasome regulatory particle lid subunit RPN13 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851140, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPN13
    Official Full Name
    proteasome regulatory particle lid subunit RPN13
    Primary source
    SGD:S000004413
    Locus tag
    YLR421C
    See related
    AllianceGenome:SGD:S000004413; FungiDB:YLR421C; VEuPathDB:YLR421C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin binding activity. Involved in ubiquitin-dependent protein catabolic process. Located in proteasome storage granule. Part of proteasome regulatory particle, lid subcomplex. Orthologous to human ADRM1 (ADRM1 26S proteasome ubiquitin receptor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPN13 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (965090..965560, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene dihydroorotase Neighboring gene Dck1p Neighboring gene protein kinase regulatory subunit ATG17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation. Peth A, et al. Mol Cell, 2010 Nov 24. PMID 21095592, Free PMC Article
    2. Mode of targeting to the proteasome determines GFP fate. Bragança CE, et al. J Biol Chem, 2020 Nov 20. PMID 32913119, Free PMC Article
    3. The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates. Martinez-Fonts K, et al. Nat Commun, 2020 Jan 24. PMID 31980598, Free PMC Article
    4. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Husnjak K, et al. Nature, 2008 May 22. PMID 18497817, Free PMC Article
    5. Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome. Rosenzweig R, et al. J Biol Chem, 2012 Apr 27. PMID 22318722, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mode of targeting to the proteasome determines GFP fate.
      Title: Mode of targeting to the proteasome determines GFP fate.
    2. Inherent asymmetry in the 26S proteasome is defined by the ubiquitin receptor RPN13.
      Title: Inherent asymmetry in the 26S proteasome is defined by the ubiquitin receptor RPN13.
    3. On the basis of the mutual positions of Rpn10 and Rpn13, we propose a model for polyubiquitin binding to the 26S proteasome
      Title: Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy.
    4. identification of a new ubiquitin receptor, Rpn13/ARM1, a known component of the proteasome
      Title: Proteasome subunit Rpn13 is a novel ubiquitin receptor.
    5. Rpn13 protein is involved in the efficient recognition of 26S proteasome for the proteolysis of ubiquitinated Gcn4p.
      Title: Rpn13p and Rpn14p are involved in the recognition of ubiquitinated Gcn4p by the 26S proteasome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome regulatory particle, lid subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in proteasome storage granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome regulatory particle lid subunit RPN13
    NP_013525.3
    • Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      965090..965560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182309.3 → NP_013525.3  TPA: proteasome regulatory particle lid subunit RPN13 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013525.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ57, O13563
      UniProtKB/TrEMBL
      A7A1U2, B3RHT1, C7GXM2, G2WJN3, N1P080
      Conserved Domains (1) summary
      pfam04683
      Location:13 → 103
      Proteasom_Rpn13; Proteasome complex subunit Rpn13 ubiquitin receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O13563.1

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