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    nup124 nucleoporin Nup124 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542254, updated on 18-Sep-2024

    Summary

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    Official Symbol
    nup124
    Official Full Name
    nucleoporin Nup124
    Primary source
    PomBase:SPAC30D11.04c
    Locus tag
    SPOM_SPAC30D11.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See nup124 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (1112175..1115868)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene transporter Hfl1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AP-3 adaptor complex subunit Aps3 Neighboring gene ncRNA Neighboring gene putative ATP-dependent RNA helicase Ddx27/Drs1 Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nup124p is a nuclear pore factor of Schizosaccharomyces pombe that is important for nuclear import and activity of retrotransposon Tf1. Balasundaram D, et al. Mol Cell Biol, 1999 Aug. PMID 10409764, Free PMC Article
    2. The functionally conserved nucleoporins Nup124p from fission yeast and the human Nup153 mediate nuclear import and activity of the Tf1 retrotransposon and HIV-1 Vpr. Varadarajan P, et al. Mol Biol Cell, 2005 Apr. PMID 15659641, Free PMC Article
    3. Multiple conserved domains of the nucleoporin Nup124p and its orthologs Nup1p and Nup153 are critical for nuclear import and activity of the fission yeast Tf1 retrotransposon. Sistla S, et al. Mol Biol Cell, 2007 Sep. PMID 17615301, Free PMC Article
    4. Selective Nuclear Pore Complex Removal Drives Nuclear Envelope Division in Fission Yeast. Expósito-Serrano M, et al. Curr Biol, 2020 Aug 17. PMID 32502403
    5. Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe. Asakawa H, et al. Nucleus, 2014 Mar-Apr. PMID 24637836, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Although full-length Nup1p or Nup153 does not complement Nup124p, the functionality of their conserved domains with reference to Tf1 activity suggests that these three proteins evolved from a common ancestor.
      Title: Multiple conserved domains of the nucleoporin Nup124p and its orthologs Nup1p and Nup153 are critical for nuclear import and activity of the fission yeast Tf1 retrotransposon.
    2. required for the nuclear import of both retrotransposon Tf1-Gag as well as the retroviral HIV-1 Vpr; Nup124 shares a unique N-terminal domain with Nup153 that is absolutely essential for Tf1 transposition
      Title: The functionally conserved nucleoporins Nup124p from fission yeast and the human Nup153 mediate nuclear import and activity of the Tf1 retrotransposon and HIV-1 Vpr.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal subunit export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitotic nuclear bridge midzone membrane domain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear envelope HDA PubMed 
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleoporin Nup124

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1112175..1115868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018609.3 → NP_593213.1  nucleoporin Nup124 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593213.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09904
      Conserved Domains (1) summary
      pfam10599
      Location:1072 → 1158
      Nup_retrotrp_bd; Retro-transposon transporting motif
    Nucleotide Protein
    Heading Accession and Version

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