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    gcn2 eIF2 alpha kinase Gcn2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540500, updated on 18-Sep-2024

    Summary

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    Official Symbol
    gcn2
    Official Full Name
    eIF2 alpha kinase Gcn2
    Primary source
    PomBase:SPBC36B7.09
    Locus tag
    SPOM_SPBC36B7.09
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ppk28; SPBP18G5.01
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    Genomic context

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    See gcn2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003423.3 (2396432..2401552)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein mug20 Neighboring gene ncRNA Neighboring gene CENP-A histone disassembly chaperone Ccp1 Neighboring gene SNARE protein Tgl1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene Tor complex Tor2-interacting protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs. Chikashige Y, et al. Nucleic Acids Res, 2020 Sep 18. PMID 32710633, Free PMC Article
    2. Differential activation of eIF2 kinases in response to cellular stresses in Schizosaccharomyces pombe. Zhan K, et al. Genetics, 2004 Dec. PMID 15611163, Free PMC Article
    3. A novel checkpoint mechanism regulating the G1/S transition. Tvegård T, et al. Genes Dev, 2007 Mar 15. PMID 17369398, Free PMC Article
    4. The G1-S checkpoint in fission yeast is not a general DNA damage checkpoint. Krohn M, et al. J Cell Sci, 2008 Dec 15. PMID 19033384
    5. Fission yeast TORC1 prevents eIF2α phosphorylation in response to nitrogen and amino acids via Gcn2 kinase. Valbuena N, et al. J Cell Sci, 2012 Dec 15. PMID 23108671

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gcn2 eIF2alpha kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs.
      Title: Gcn2 eIF2α kinase mediates combinatorial translational regulation through nucleotide motifs and uORFs in target mRNAs.
    2. Gcn2 and eIF2a phosphorylation are involved in the modulation of G1 phase cell cycle arrest, cell survival and mating under nutritional stress in the fission yeast Schizosaccharomyces pombe.
      Title: New roles of the fission yeast eIF2α kinases Hri1 and Gcn2 in response to nutritional stress.
    3. S. pombe Cpc2 facilitates the GAAC response through the regulation of Gcn2 activation
      Title: Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast.
    4. Gcn2 is the primary eIF2 kinase induced during a nutrient downshift, treatment with the amino acid biosynthetic inhibitor 3-aminotriazole or upon exposure to high NaCl concentrations. It is tandemly activated with Hri2 in response to H2O2 exposure. [Gcn2]
      Title: Differential activation of eIF2 kinases in response to cellular stresses in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1 to G0 transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in GCN2-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G1 DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytoplasmic translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cytoplasmic translational initiation in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translational initiation in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eIF2 alpha kinase Gcn2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2396432..2401552
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021898.3 → NP_595991.2  eIF2 alpha kinase Gcn2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595991.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q66T01, Q9HDW2, Q9HGN1
      Conserved Domains (7) summary
      smart00220
      Location:556 → 915
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0124
      Location:990 → 1417
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd14012
      Location:241 → 508
      PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cd14046
      Location:549 → 917
      STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      pfam05773
      Location:10 → 124
      RWD; RWD domain
      pfam12745
      Location:1326 → 1576
      HGTP_anticodon2; Anticodon binding domain of tRNAs
      cl00268
      Location:990 → 1295
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
    Nucleotide Protein
    Heading Accession and Version

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