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    ppe1 serine/threonine protein phosphatase PP6 catalytic subunit Ppe1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538758, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ppe1
    Official Full Name
    serine/threonine protein phosphatase PP6 catalytic subunit Ppe1
    Primary source
    PomBase:SPCC1739.12
    Locus tag
    SPOM_SPCC1739.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ekc2; esp1; ppx1
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    Genomic context

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    See ppe1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (2053511..2057069)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein mug33 Neighboring gene SIN component scaffold protein cdc11 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene heat shock protein Ssa2 Neighboring gene ncRNA Neighboring gene nucleoporin Npp106

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction of the pim1/spi1 mitotic checkpoint with a protein phosphatase. Matsumoto T, et al. Mol Biol Cell, 1993 Mar. PMID 8387358, Free PMC Article
    2. Glucose controls phosphoregulation of hydroxymethylglutaryl coenzyme A reductase through the protein phosphatase 2A-related phosphatase protein, Ppe1, and Insig in fission yeast. Burg JS, et al. J Biol Chem, 2011 Aug 5. PMID 21680738, Free PMC Article
    3. A calcineurin-like gene ppb1+ in fission yeast: mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning. Yoshida T, et al. J Cell Sci, 1994 Jul. PMID 7983142
    4. The role of Ppe1/PP6 phosphatase for equal chromosome segregation in fission yeast kinetochore. Goshima G, et al. EMBO J, 2003 Jun 2. PMID 12773390, Free PMC Article
    5. A novel protein kinase gene ssp1+ is required for alteration of growth polarity and actin localization in fission yeast. Matsusaka T, et al. EMBO J, 1995 Jul 17. PMID 7628434, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. regulation of Hmg1 phosphorylation requires the protein phosphatase 2A-related phosphatase Ppe1 and its regulator Sds23
      Title: Glucose controls phosphoregulation of hydroxymethylglutaryl coenzyme A reductase through the protein phosphatase 2A-related phosphatase protein, Ppe1, and Insig in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    part_of protein serine/threonine phosphatase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein phosphatase PP6 catalytic subunit Ppe1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      2053511..2057069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023411.3 → NP_588420.1  serine/threonine protein phosphatase PP6 catalytic subunit Ppe1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588420.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P36614
      Conserved Domains (2) summary
      PTZ00239
      Location:3 → 296
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional
      cd07415
      Location:3 → 287
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version

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